Bioavailability of Sublingual Buprenorphine

@article{Mendelson1997BioavailabilityOS,
  title={Bioavailability of Sublingual Buprenorphine},
  author={John E. Mendelson and Robert A. Upton and E. Thomas Everhart and Peyton Jacob Iii and Reese T. Jones},
  journal={The Journal of Clinical Pharmacology},
  year={1997},
  volume={37}
}
Buprenorphine administered sublingually is a promising treatment for opiate dependence. Utilizing a new, sensitive, and specific gas chromatographic electron‐capture detector assay, the absolute bioavailability of sublingual buprenorphine was determined in six healthy volunteers by comparing plasma concentrations after 3‐ and 5‐minute exposures to 2 mg sublingual and 1 mg intravenous buprenorphine. The amount of unabsorbed buprenorphine in saliva was measured after 2‐, 4‐, and 10‐minute… Expand
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