Bioavailability of Nalidixic acid from uncoated tablets in humans--Part II: Bioavailability in beagles and its correlation with bioavailability in humans and in vitro dissolution rates.


The bioavailability of nalidixic acid in beagles was determined using the same tablet formulations previously tested on humans and was compared with bioavailability in humans and with in vitro dissolution rates. The beagle bioavailability test provided lower power in all of the bioavailability parameters than did the human test. Tmax of the tablets did not… (More)


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