Bioavailability of Apigenin from Apiin-Rich Parsley in Humans

@article{Meyer2006BioavailabilityOA,
  title={Bioavailability of Apigenin from Apiin-Rich Parsley in Humans},
  author={Hellen Meyer and Adrian Bolarinwa and G. Wolfram and Jakob Linseisen},
  journal={Annals of Nutrition and Metabolism},
  year={2006},
  volume={50},
  pages={167 - 172}
}
Aim: Absorption and excretion of apigenin after the ingestion of apiin-rich food, i.e. parsley, was tested. [] Key Method Blood samples were taken at 0, 4, 6, 7, 8, 9, 10, 11 and 28 h after parsley consumption and 24-hour urine samples were collected. Apigenin was analyzed in plasma, urine and red blood cells by means of HPLC-ECD. Results: On average, a maximum apigenin plasma concentration of 127 ± 81 nmol/l was reached after 7.2 ± 1.3 h with a high range of variation between subjects.

Figures and Tables from this paper

Inhibitory Effect of Apigenin on Pharmacokinetics of Venlafaxine in vivo and in vitro
TLDR
It is indicated that an intake of apigenin could increase VEN plasma levels and some of its pharmacokinetic parameters (AUC, Tmax) and more attention should be paid when VEN was administrated combined with apigen in.
The bioavailability of apigenin-7-glucoside is influenced by human intestinal microbiota in rats.
TLDR
Overall, human intestinal microbiota largely contributed to A7G metabolism, indicating its influence on the bioactivity of flavones.
Pharmacokinetic properties and drug interactions of apigenin, a natural flavone
TLDR
Apigenin has value as a good cellular regulator in cancer, especially cancers of the gastrointestinal tract, and novel carriers would need to be developed to enhance the oral bioavailability of apigenin.
Does Oral Apigenin Have Real Potential for a Therapeutic Effect in the Context of Human Gastrointestinal and Other Cancers?
TLDR
It is found that oral intake of dietary materials would require heroic ingestion amounts and is not feasible, but use of supplements of semi-purified apigenin in capsule form could reach target blood levels using amounts that are within the range currently acceptable for other supplements and medications.
The Effect of Apigenin on Pharmacokinetics of Imatinib and Its Metabolite N-Desmethyl Imatinib in Rats
TLDR
Results indicated that apigenin in the short-term study inhibited the metabolism of imatinib and its metabolite N-desmethyl imatinIB, while in the long- term study the metabolism could be accelerated.
Apigenin and its impact on gastrointestinal cancers.
TLDR
Apigenin is able to reduce cancer cell glucose uptake, inhibit remodeling of the extracellular matrix, inhibit cell adhesion molecules that participate in cancer progression, and oppose chemokine signaling pathways that direct the course of metastasis into other locations.
Flavones: Food Sources, Bioavailability, Metabolism, and Bioactivity 1,2
TLDR
A better understanding of flavone sources and bioavailability is needed to understand mechanisms of action and nutritional intervention.
The relationship between fasting plasma concentrations of selected flavonoids and their ordinary dietary intake.
TLDR
The present results suggest that quercetin, kaempferol, isorhamnetin, apigenin and luteolin are bioavailable from the diet and the levels of fasting plasma flavonoids seem to be suitable biomarkers of short-term intake.
...
...

References

SHOWING 1-10 OF 28 REFERENCES
Effect of parsley (Petroselinum crispum) intake on urinary apigenin excretion, blood antioxidant enzymes and biomarkers for oxidative stress in human subjects
TLDR
In this short-term investigation, an overall decreasing trend in the activity of antioxidant enzymes was observed and the intervention with parsley seemed, partly, to overcome this decrease and resulted in increased levels of GR and SOD.
Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study.
TLDR
The antiaggregatory effects of flavonoids seen in vitro are due to concentrations that cannot be attained in vivo, and effects of dietary flavonols and flavones on cardiovascular risk are possibly not mediated by hemostatic variables.
Metabolism of Flavonoids via Enteric Recycling: Role of Intestinal Disposition
TLDR
In conclusion, intestinal disposition may be more important than hepatic disposition in the first-pass metabolism of flavonoids such as apigenin and enteric recycling may be used to explain why flavonoid have poor systemic bioavailabilities.
The role of antioxidant phytonutrients in the prevention of diseases
The authors investigated the in vitro antioxidant properties of nine selected flavonoid aglycons, namely quercetin, kaempferol, myricetin, apigenin, luteolin, daidzein, genistein, formononetin and
Polyphenols: food sources and bioavailability.
TLDR
The nature and contents of the various polyphenols present in food sources and the influence of agricultural practices and industrial processes are reviewed, and bioavailability appears to differ greatly between the variousPolyphenols, and the most abundantpolyphenols in the authors' diet are not necessarily those that have the best bioavailability profile.
Metabolism of apigenin by rat liver phase I and phase ii enzymes and by isolated perfused rat liver.
TLDR
New data is provided about the metabolism of apigenin and the interest value of using various experimental models in metabolic studies is shown.
Flavonols, flavones and flavanols: nature, occurrence and dietary burden
TLDR
Total flavonol and flavone contents of foods have been determined with validated state-of-the-art methods and attention is needed for the identification and quantification of their metabolites in body fluids.
Diuretic effect and mechanism of action of parsley.
Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice.
TLDR
Data indicate that apigenin inhibited skin papillomas and showed the tendency to decrease conversion of papilloma to carcinomas.
...
...