Bioavailability of Apigenin from Apiin-Rich Parsley in Humans
@article{Meyer2006BioavailabilityOA, title={Bioavailability of Apigenin from Apiin-Rich Parsley in Humans}, author={Hellen Meyer and Adrian Bolarinwa and G. Wolfram and Jakob Linseisen}, journal={Annals of Nutrition and Metabolism}, year={2006}, volume={50}, pages={167 - 172} }
Aim: Absorption and excretion of apigenin after the ingestion of apiin-rich food, i.e. parsley, was tested. [] Key Method Blood samples were taken at 0, 4, 6, 7, 8, 9, 10, 11 and 28 h after parsley consumption and 24-hour urine samples were collected. Apigenin was analyzed in plasma, urine and red blood cells by means of HPLC-ECD. Results: On average, a maximum apigenin plasma concentration of 127 ± 81 nmol/l was reached after 7.2 ± 1.3 h with a high range of variation between subjects.
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References
SHOWING 1-10 OF 28 REFERENCES
Effect of parsley (Petroselinum crispum) intake on urinary apigenin excretion, blood antioxidant enzymes and biomarkers for oxidative stress in human subjects
- Biology, MedicineBritish Journal of Nutrition
- 1999
In this short-term investigation, an overall decreasing trend in the activity of antioxidant enzymes was observed and the intervention with parsley seemed, partly, to overcome this decrease and resulted in increased levels of GR and SOD.
Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study.
- Medicine, BiologyThe American journal of clinical nutrition
- 1998
The antiaggregatory effects of flavonoids seen in vitro are due to concentrations that cannot be attained in vivo, and effects of dietary flavonols and flavones on cardiovascular risk are possibly not mediated by hemostatic variables.
Metabolism of Flavonoids via Enteric Recycling: Role of Intestinal Disposition
- Biology, ChemistryJournal of Pharmacology and Experimental Therapeutics
- 2003
In conclusion, intestinal disposition may be more important than hepatic disposition in the first-pass metabolism of flavonoids such as apigenin and enteric recycling may be used to explain why flavonoid have poor systemic bioavailabilities.
The role of antioxidant phytonutrients in the prevention of diseases
- Chemistry
- 2003
The authors investigated the in vitro antioxidant properties of nine selected flavonoid aglycons, namely quercetin, kaempferol, myricetin, apigenin, luteolin, daidzein, genistein, formononetin and…
Polyphenols: food sources and bioavailability.
- BiologyThe American journal of clinical nutrition
- 2004
The nature and contents of the various polyphenols present in food sources and the influence of agricultural practices and industrial processes are reviewed, and bioavailability appears to differ greatly between the variousPolyphenols, and the most abundantpolyphenols in the authors' diet are not necessarily those that have the best bioavailability profile.
Metabolism of apigenin by rat liver phase I and phase ii enzymes and by isolated perfused rat liver.
- Biology, ChemistryDrug metabolism and disposition: the biological fate of chemicals
- 2004
New data is provided about the metabolism of apigenin and the interest value of using various experimental models in metabolic studies is shown.
Flavonols, flavones and flavanols: nature, occurrence and dietary burden
- Chemistry
- 2000
Total flavonol and flavone contents of foods have been determined with validated state-of-the-art methods and attention is needed for the identification and quantification of their metabolites in body fluids.
Diuretic effect and mechanism of action of parsley.
- BiologyJournal of ethnopharmacology
- 2002
Column-switching high-performance liquid chromatographic assay for determination of apigenin and acacetin in human urine with ultraviolet absorbance detection.
- ChemistryJournal of chromatography. B, Biomedical sciences and applications
- 1998
Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice.
- Medicine, BiologyCancer research
- 1990
Data indicate that apigenin inhibited skin papillomas and showed the tendency to decrease conversion of papilloma to carcinomas.