Bioavailability estimation by semisimultaneous drug administration: A Monte Carlo simulation study


The performance of a novel method for determination of drug absorption characteristics was evaluated by Monte Carlo simulations. In bioavailability studies with use of this method, the test and the reference doses are administered within a time interval of hours. Estimates of bioavilability are obtained by fitting an appropriate model to the… (More)
DOI: 10.1007/BF01063554


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