Bioavailability and pharmacokinetics of oxazepam

@article{Sonne2004BioavailabilityAP,
  title={Bioavailability and pharmacokinetics of oxazepam},
  author={Jesper Sonne and Steffen Loft and Martin D{\o}ssing and Anne Vollmer-Larsen and K. -L. Olesen and M A Victor and Frederik Andreasen and Per Buch Andreasen},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={35},
  pages={385-389}
}
SummarySix healthy volunteers received oxazepam 15 mg i.v. and orally at an interval of at least one week. The kinetic variables of i.v. oxazepam were: elimination half-life (t1/2β) 6.7 h, total clearance (CL) 1.07 ml·min−1·kg−1, volume of distribution (Vc) 0.27 l·kg−1 (0.21–0.49) and volume of distribution at steady-state (Vss) 0.59 l·kg−1. The intravenous disposition of unbound oxazepam was characterized by a clearance of 22.5ml·min−1·kg−1 and a distribution volume of 12.3 l·kg−1. After oral… 
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