Bioavailability and pharmacokinetics of oral and injectable formulations of methadone after intravenous, oral, and intragastric administration in horses.

@article{Linardi2012BioavailabilityAP,
  title={Bioavailability and pharmacokinetics of oral and injectable formulations of methadone after intravenous, oral, and intragastric administration in horses.},
  author={Renata Lehn Linardi and Ashley M Stokes and Michael Layne Keowen and Steven A. Barker and Giselle Hosgood and Charles R Short},
  journal={American journal of veterinary research},
  year={2012},
  volume={73 2},
  pages={290-5}
}
OBJECTIVE To characterize the bioavailability and pharmacokinetics of oral and injectable formulations of methadone after IV, oral, and intragastric administration in horses. ANIMALS 6 healthy adult horses. PROCEDURES Horses received single doses (each 0.15 mg/kg) of an oral formulation of methadone hydrochloride orally or intragastrically or an injectable formulation of the drug orally, intragastrically, or IV (5 experimental treatments/horse; 2-week washout period between each… CONTINUE READING

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