Bioavailability and pharmacokinetics of a praziquantel bolus in kingfish Seriola lalandi.

@article{Tubbs2006BioavailabilityAP,
  title={Bioavailability and pharmacokinetics of a praziquantel bolus in kingfish Seriola lalandi.},
  author={Lincoln Tubbs and Malcolm Drummond Tingle},
  journal={Diseases of aquatic organisms},
  year={2006},
  volume={69 2-3},
  pages={233-8}
}
Oral praziquantel (PZQ) preparations have recently been investigated for the treatment of monogeneans that infect the skin and gills of kingfish Seriola lalandi cultured in sea-cages. To evaluate an oral PZQ dosing strategy, the pharmacokinetics of a dissolved and in feed oral PZQ preparation (40 mg kg(-1) body weight) were compared with an intravenous bolus in kingfish plasma and skin using HPLC. Compared with intravenous administration, PZQ bioavailability (area under curve, AUC0-24h) was… CONTINUE READING
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