Bioavailability and metabolism of hydroquinone after intratracheal instillation in male rats.

@article{Deisinger1999BioavailabilityAM,
  title={Bioavailability and metabolism of hydroquinone after intratracheal instillation in male rats.},
  author={P J Deisinger and J. Caroline English},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1999},
  volume={27 4},
  pages={442-8}
}
The purpose of this study was to investigate the rate and extent of hydroquinone (HQ) absorption and first pass metabolism in the lungs of male rats in vivo. [14C]HQ in physiological saline was administered intratracheally via an indwelling endotracheal tube to simulate inhalation exposure to HQ dust. The bioavailability of HQ was determined by blood… CONTINUE READING