Bioavailability and Risk Assessment of Orally Ingested Polycyclic Aromatic Hydrocarbons

@article{Ramesh2004BioavailabilityAR,
  title={Bioavailability and Risk Assessment of Orally Ingested Polycyclic Aromatic Hydrocarbons},
  author={Aramandla Ramesh and Stormy A. Walker and Darryl B Hood and Mar{\'i}a D Guill{\'e}n and Klaus Schneider and Eric H. Weyand},
  journal={International Journal of Toxicology},
  year={2004},
  volume={23},
  pages={301 - 333}
}
Polycyclic aromatic hydrocarbons (PAHs) are a family of toxicants that are ubiquitous in the environment. These contaminants generate considerable interest, because some of them are highly carcinogenic in laboratory animals and have been implicated in breast, lung, and colon cancers in humans. These chemicals commonly enter the human body through inhalation of cigarette smoke or consumption of contaminated food. Of these two pathways, dietary intake of PAHs constitutes a major source of… 

Figures and Tables from this paper

A Critical Review about the Health Risk Assessment of PAHs and Their Metabolites in Foods

TLDR
Based on intake, disposition, and tumorigenesis data, the exposure risk to PAHs from diet is presented and is expected to provide a framework for refinements in risk assessment ofPAHs.

Polycyclic Aromatic Hydrocarbons and Digestive Tract Cancers: A Perspective

  • D. L. DiggsA. Huderson A. Ramesh
  • Medicine
    Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews
  • 2011
TLDR
Dietary intake of PAHs in humans, animal models, and cell cultures used for GI cancer studies along with epidemiological findings are focused on to stimulate research on mechanisms of sporadic GI cancers caused by exposure to environmental carcinogens.

Polycyclic Aromatic Hydrocarbons (PAHs) and their Bioaccessibility in Meat: a Tool for Assessing Human Cancer Risk.

TLDR
An in vitro human digestion model was chosen for assessing the bioaccessibility of PAHs in food as it offers a simple, rapid, low cost alternative to human and animal studies; providing insights which may not be achievable in in vivo studies.

Bioaccessibility of polycyclic aromatic hydrocarbons: relevance to toxicity and carcinogenesis

TLDR
While bioaccessibility is a promising approach for assessing PAH risk arising from various types of contaminated soils, none of the models proposed appears to be valid.

Human dietary exposure to polycyclic aromatic hydrocarbons: A review of the scientific literature.

  • J. DomingoM. Nadal
  • Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2015

Polycyclic Aromatic Hydrocarbons (PAHs) and Their Influence to Some Aquatic Species

  • A. BaaliA. Yahyaoui
  • Environmental Science
    Biochemical Toxicology - Heavy Metals and Nanomaterials
  • 2020
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants generated primarily during the incomplete combustion of organic materi-als (e.g., coal, oil, petrol, and wood). Many

Role of Pet Dogs and Cats as Sentinels of Human Exposure to Polycyclic Aromatic Hydrocarbons

TLDR
The scarce data available indicate that dogs and cats seem to have different sources of exposition to PAHs than humans, and although more studies are needed, pets do not seem to be good sentinels for human exposure toPAHs.

Importance of Dermal Absorption of Polycyclic Aromatic Hydrocarbons Derived from Barbecue Fumes.

TLDR
In the case of BBQ fumes, dermal absorption was a more important pathway for intake of low molecular-weight PAHs than inhalation.

The ability of polycyclic aromatic hydrocarbons to alter physiological factors underlying drug disposition

TLDR
The pharmacokinetic properties of PAH, the possible mechanisms by which they can alter drug disposition, and specific examples are discussed.
...

References

SHOWING 1-10 OF 349 REFERENCES

Polycyclic aromatic hydrocarbons in the diet.

Determination of Polycyclic Aromatic Hydrocarbons (PAH) and Their Metabolites in Blood, Feces, and Urine of Rats Orally Exposed to PAH Contaminated Soils

TLDR
The results indicate that the dosed PAH are largely absorbed by the gastrointestinal tract, subsequently metabolized and excreted as metabolites via urine and feces, and suggest that exposure risk assessment models assuming complete bioavailability of soilmatrix-bound PAH probably overestimate the endogenous dose.

Intestinal Absorption of Carcinogenic Hydrocarbons

TLDR
It is important to recognize that this group of compounds forms a class of substances such that, although the concentration of any individual compound in a particular food may be relatively low, the total amount of these substances delivered in certain foods may be significant and they should be considered as an epidemiological group.

Food as a Source of Polycyclic Aromatic Carcinogens

TLDR
The presence of PAH in foodstuffs should be reduced to as low as possible by controlling environmental contamination and all procedures that could cause PAH contamination during food processing, preserving, and packaging.

Studies on the applicability of biomarkers in estimating the systemic bioavailability of polynuclear aromatic hydrocarbons from manufactured gas plant tar-contaminated soils

The systemic bioavailability of polynuclear aromatic hydrocarbons (PAH) from ingested soils containing manufactured gas plant (MGP) tar was evaluated in mice. Soil and organic extract of each soil

Dietary effects on the uptake of benzo[a]pyrene.

  • B. StavricR. Klassen
  • Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1994

Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air.

TLDR
Fluoranthene is an important volatile PAH because it occurs at high concentrations in ambient air and because it is an experimental carcinogen in certain test systems, and a tentative guideline value of 2 ng/m(3) is suggested for fluoranthene.

Assessment of carcinogenic risk from personal exposure to benzo(a)pyrene in the Total Human Environmental Exposure Study (THEES).

TLDR
The total lifetime risk from personal exposure to BaP for nonsmokers in the community was estimated at 10(-5), and in identifying risk reduction options, it is important to account for the observation that personal activities, lifestyle, and diet strongly influenced individual exposures toBaP.

Provisional guidance for quantitative risk assessment of polycyclic aromatic hydrocarbons. Final report

PAHs are products of incomplete combustion of organic materials; sources are, thus, widespread including cigarette smoke, municipal waste incineration, wood stove emissions, coal conversion, energy

The formation and occurrence of polynuclear aromatic hydrocarbons associated with food.

...