Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update
@article{RodriguezMateos2014BioavailabilityBA, title={Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update}, author={Ana Rodriguez-Mateos and Dr David Vauzour and Christian G. Krueger and Dhanansayan Shanmuganayagam and Jess D. Reed and Luca Calani and Pedro Mena and Daniele Del Rio and Alan Crozier}, journal={Archives of Toxicology}, year={2014}, volume={88}, pages={1803-1853} }
There is substantial interest in the role of plant secondary metabolites as protective dietary agents. In particular, the involvement of flavonoids and related compounds has become a major topic in human nutrition research. Evidence from epidemiological and human intervention studies is emerging regarding the protective effects of various (poly)phenol-rich foods against several chronic diseases, including neurodegeneration, cancer and cardiovascular diseases. In recent years, the use of HPLC–MS…
426 Citations
The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective.
- BiologyComprehensive reviews in food science and food safety
- 2018
This review traces the development of the field over the past 8 decades, and indicates the current state of the art, and how it was reached.
Phenolic compounds in fruits and beverages consumed as part of the mediterranean diet: their role in prevention of chronic diseases
- MedicinePhytochemistry Reviews
- 2015
The level of evidence for a beneficial effect in humans of phenolic compounds on the prevention of CDs is weak and need to be strengthened by additional studies addressing potential confounding factors, such as interaction of phenols with other bioactive substances in foods and potential pro-oxidant effects.
Flavonoids at the pharma-nutrition interface: Is a therapeutic index in demand?
- MedicineBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- 2015
Absorption Profile of (Poly)Phenolic Compounds after Consumption of Three Food Supplements Containing 36 Different Fruits, Vegetables, and Berries
- Chemistry, MedicineNutrients
- 2017
Investigation of the absorption profile of the (poly)phenolic compounds contained in three different plant-based food supplements, made of 36 different plant matrices, showed that the consumption of the three capsules allowed the effective absorption of several ( poly) Phenolic compounds and metabolites appearing at different times in plasma, thereby indicating different absorption profiles.
Dietary Flavonoids as Cancer Chemopreventive Agents: An Updated Review of Human Studies
- MedicineAntioxidants
- 2019
It is concluded that dietary flavonoid intake is associated with a reduced risk of different types of cancer, such as gastric, breast, prostate, and colorectal cancers.
Investigating the impact of flavonoid metabolites on endothelial function and vascular inflammation
- Biology
- 2016
Data herein suggest multiple mechanisms are modulated by flavonoid metabolites which contributes to the authors' understanding of how flavonoids influence physiological responses, and therefore the associations between diet and health.
Factors affecting intake, metabolism and health benefits of phenolic acids: do we understand individual variability?
- BiologyEuropean Journal of Nutrition
- 2019
A better understanding of the gut-host interplay and microbiome biochemistry is becoming highly relevant in understanding the impact of diet and its constituents, and it should be preferred that health responders and non-responders are studied in combination with explanatory metabolite profiles and gene variants.
Physiological relevance of food antioxidants.
- Biology, MedicineAdvances in food and nutrition research
- 2020
Bioaccessibility and bioavailability of phenolic compounds in bread: a review.
- Chemistry, MedicineFood & function
- 2017
Overall, the findings suggest that several strategies can be used to develop new bread products with greater phenolic bioaccessibility and bioavailability, however, due to the large variability and the few studies available, further investigations are required to determine better the usefulness of these innovative processes.
References
SHOWING 1-10 OF 472 REFERENCES
Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases.
- Biology, MedicineAntioxidants & redox signaling
- 2013
It is concluded that better performed in vivo intervention and in vitro mechanistic studies are needed to fully understand how (poly)phenol molecules interact with human physiological and pathological processes.
Fruit polyphenols, immunity and inflammation
- BiologyBritish Journal of Nutrition
- 2010
Evidence for the effects of fruit and tea flavonoids and their metabolites in inflammation and immunity is summarized and Mechanisms of effect are discussed, including those on enzyme function and regulation of gene and protein expression.
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies.
- MedicineThe American journal of clinical nutrition
- 2005
Gallic acid and isoflavones are the most well-absorbed polyphenols, followed by catechins, flavanones, and quercetin glucosides, but with different kinetics, and the least well- absorption polyphenol are the proanthocyanidins, the galloylated tea catech ins, andThe anthocyanins.
Bioavailability of dietary flavonoids and phenolic compounds.
- BiologyMolecular aspects of medicine
- 2010
Anti-estrogenic activity of a human resveratrol metabolite.
- BiologyNutrition, metabolism, and cardiovascular diseases : NMCD
- 2013
Antioxidant and antiproliferative properties of methylated metabolites of anthocyanins.
- Chemistry, MedicineFood chemistry
- 2013
Structurally related (-)-epicatechin metabolites in humans: assessment using de novo chemically synthesized authentic standards.
- BiologyFree radical biology & medicine
- 2012
Phenol-Explorer: an online comprehensive database on polyphenol contents in foods
- Medicine, Computer ScienceDatabase J. Biol. Databases Curation
- 2010
Phenol-Explorer is the first comprehensive web-based database on polyphenol content in foods and should help researchers to better understand the role of phytochemicals in the technical and nutritional quality of food, and food manufacturers to develop tailor-made healthy foods.
The food metabolome: a window over dietary exposure.
- BiologyThe American journal of clinical nutrition
- 2014
Key recommendations made during the workshop included more coordination of efforts; development of new databases, software tools, and chemical libraries for the food metabolome; and shared repositories of metabolomic data.