Bioassay of thyroid-stimulating immunoglobulins using human thyroid cell cultures: optimization and clinical assessment.

@article{Bidey1983BioassayOT,
  title={Bioassay of thyroid-stimulating immunoglobulins using human thyroid cell cultures: optimization and clinical assessment.},
  author={S P Bidey and N. Justin Marshall and R P Ekins},
  journal={Clinical endocrinology},
  year={1983},
  volume={19 2},
  pages={193-206}
}
Primary monolayer cultures of human thyroid cells have been used to investigate the intracellular cyclic AMP response to thyroid-stimulating immunoglobulins (TSIg) prepared from the sera of patients with Graves' disease. In particular, attention was directed towards dose-response characteristics obtained under differing incubation conditions, and an optimized incubation procedure based upon conditions consistent with the maximal precision of TSIg measurement was developed. The magnitude of the… CONTINUE READING
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