Bioassay-guided isolation of aldose reductase inhibitors from Artemisia dracunculus.

@article{Logendra2006BioassayguidedIO,
  title={Bioassay-guided isolation of aldose reductase inhibitors from Artemisia dracunculus.},
  author={Sithes Logendra and David Ribnicky and Hui Yang and Alexander A. Poulev and Jun Ma and Edward J. Kennelly and Ilya Raskin},
  journal={Phytochemistry},
  year={2006},
  volume={67 14},
  pages={1539-46}
}
An ethanolic extract of Artemisia dracunculus L. having antidiabetic activity was examined as a possible aldose reductase (ALR2) inhibitor, a key enzyme involved in diabetic complications. At 3.75 microg/mL, the total extract inhibited ALR2 activity by 40%, while quercitrin, a known ALR2 inhibitor, inhibited its activity by 54%. Bioactivity guided fractionation and isolation of the compounds that inhibit ALR2 activity was carried out with the total ethanolic extract yielding four bioactive… CONTINUE READING

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