Bioassay for carcinogenicity of 3,2'-dimethyl-4-nitrosobiphenyl, O-nitrosotoluene, nitrosobenzene and the corresponding amines in Syrian golden hamsters.

@article{Hecht1983BioassayFC,
  title={Bioassay for carcinogenicity of 3,2'-dimethyl-4-nitrosobiphenyl, O-nitrosotoluene, nitrosobenzene and the corresponding amines in Syrian golden hamsters.},
  author={Stephen S. Hecht and Karam El-Bayoumy and Abraham Rivenson and Emerich S. Fiala},
  journal={Cancer letters},
  year={1983},
  volume={20 3},
  pages={
          349-54
        }
}
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3.5 – Ortho-Toluidine

References

SHOWING 1-10 OF 14 REFERENCES
Comparative carcinogenicity of o-toluidine hydrochloride and o-nitrosotoluene in F-344 rats.
The effect of disulfiram on the carcinogenicity of 3,2'dimethyl-4-aminopbiphenyl in Syrian golden hamsters and rats.
TLDR
The addition of disulfiram in the diet reduced the incidence of cancers of the small intestine, similar to the effects of hamsters, but resulted in the occurrence of a small number of bladder cancers.
Testing of twenty-one environmental aromatic amines or derivatives for long-term toxicity or carcinogenicity.
TLDR
Twenty-one aromatic amines or derivatives were tested for long-term toxicity by dietary administration to male Charles River rats and male and female HaM/lCR mice, and four inactive compounds included m-phenyl-enediamine, 2,4-dinitrochlorobenzene, benzoguanamine, and dicyclopentadiene dioxide.
In vivo metabolism of 3,2'-dimethyl-4-aminobiphenyl (DMAB) bearing on its organotropism in the Syrian golden hamster and the F344 rat.
The in vivo metabolism of tritiated DMAB was examined in male Syrian golden hamsters, which are susceptible to both urinary bladder and intestinal carcinogenesis by this agent and in male F344 rats…
Prostate adenocarcinoma in rats: induction by 3,2'-dimethyl-4-aminobiphenyl.
TLDR
It is shown that DMAB can induce adenocarcinomas in the rat prostate gland and that none of the control animals exhibited prostate neoplasms.
The Carcinogenic Action of 4-Aminodiphenyl and 3:2'-Dimethyl-4-Aminodiphenyl
TLDR
No reliable experimental evidence that either aniline, toluidines, or xylidines are carcinogenic is found, although a variety of other aromatic compounds have been suspected.
Effect of intestinal microflora on 2,2'-dimethyl-4-aminobiphenyl-induced carcinogenesis in F344 rats.
TLDR
DMAB induced fewer intestinal and breast tumors in germfree rats than in conventional rats, and the incidence of intestinal tumors was lower in the germfree Rats than inventional animals.
Inhibition of Amino Acid Incorporation in vitro by Metabolites of 2-Acetylaminofluorene and by Certain Nitroso Compounds.∗
Summary 2-Nitrosofluorene, 2-nitrosotolu-ene, and nitrosobenzene, at concentrations of 5 × 10-5 M or greater inhibited the incorporation of amino acids into protein by a rat liver microsome-pH 5…
Studies on the enzymatic reduction of C-nitroso compounds. IV. Partial purification and kinetic properties of porcine heart C-nitrosoreductase.
An NAD(P)H-dependent C-nitrosoreductase was purified 90 fold from porcine heart cytosol fraction by ammonium sulfate fractionation, gel filtration with Sephadex G-100, ion-exchange chromatography on…
Nonenzymatic reduction of nitrosobenzene to phenylhydroxylamine by NAD(P)H
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