Bioassay for carcinogenicity of 3,2'-dimethyl-4-nitrosobiphenyl, O-nitrosotoluene, nitrosobenzene and the corresponding amines in Syrian golden hamsters.

  title={Bioassay for carcinogenicity of 3,2'-dimethyl-4-nitrosobiphenyl, O-nitrosotoluene, nitrosobenzene and the corresponding amines in Syrian golden hamsters.},
  author={Stephen S. Hecht and Karam El-Bayoumy and Abraham Rivenson and Emerich S. Fiala},
  journal={Cancer letters},
  volume={20 3},
Aniline: early indicators of toxicity in male rats and their relevance to spleen carcinogenicity
Results corroborate the contention that carcinogenic doses of aniline cause early effects on haematological parameters, inflammatory reaction in the spleen and perturbations in iron metabolism as a result of haemolytic anaemia and may be linked to definable threshold-related processes.
Toxicological and Environmental Aspects of Anilines
1 Introduction 2 Cyanosis 3 Analytical Methods for Environmental Detection and Sampling of Anilines 4 Carcinoma 5 Mechanism of Bladder Cancer 6 Specific Aromatic Amines 7
Exposure Data 1 . 1 Identification of the agent 1
Description: Yellowish crystals or powder with a characteristic sulfurous odour (IFA, 2015) Melting point: 180–182 °C (HSDB, 2015) Density (at 20 °C): 1.42 g/cm3 (HSDB, 2015) Octanol/water partition
NMR and Computational Characterization of Protein Structure and Ligand Binding
NMR techniques combined with computational methods such as docking and cheminformatics were used to characterize protein structure and ligand binding, and docking and NMR chemical shift perturbation experiments show promise for the inhibition of the thioredoxin C-thiOREDoxin reductase catalytic turnover.
Aniline: Evaluation of risks to health from environmental exposure in Canada
It is concluded that aniline is “possibly carcinogenic to humans” and is included on the List of Priority Substances to be assessed under the Canadian Environmental Protection Act.


The effect of disulfiram on the carcinogenicity of 3,2'dimethyl-4-aminopbiphenyl in Syrian golden hamsters and rats.
The addition of disulfiram in the diet reduced the incidence of cancers of the small intestine, similar to the effects of hamsters, but resulted in the occurrence of a small number of bladder cancers.
Testing of twenty-one environmental aromatic amines or derivatives for long-term toxicity or carcinogenicity.
Twenty-one aromatic amines or derivatives were tested for long-term toxicity by dietary administration to male Charles River rats and male and female HaM/lCR mice, and four inactive compounds included m-phenyl-enediamine, 2,4-dinitrochlorobenzene, benzoguanamine, and dicyclopentadiene dioxide.
In vivo metabolism of 3,2'-dimethyl-4-aminobiphenyl (DMAB) bearing on its organotropism in the Syrian golden hamster and the F344 rat.
The in vivo metabolism of tritiated DMAB was examined in male Syrian golden hamsters, which are susceptible to both urinary bladder and intestinal carcinogenesis by this agent and in male F344 rats
Prostate adenocarcinoma in rats: induction by 3,2'-dimethyl-4-aminobiphenyl.
It is shown that DMAB can induce adenocarcinomas in the rat prostate gland and that none of the control animals exhibited prostate neoplasms.
The Carcinogenic Action of 4-Aminodiphenyl and 3:2'-Dimethyl-4-Aminodiphenyl
No reliable experimental evidence that either aniline, toluidines, or xylidines are carcinogenic is found, although a variety of other aromatic compounds have been suspected.
Effect of intestinal microflora on 2,2'-dimethyl-4-aminobiphenyl-induced carcinogenesis in F344 rats.
DMAB induced fewer intestinal and breast tumors in germfree rats than in conventional rats, and the incidence of intestinal tumors was lower in the germfree Rats than inventional animals.
Inhibition of Amino Acid Incorporation in vitro by Metabolites of 2-Acetylaminofluorene and by Certain Nitroso Compounds.∗
Summary 2-Nitrosofluorene, 2-nitrosotolu-ene, and nitrosobenzene, at concentrations of 5 × 10-5 M or greater inhibited the incorporation of amino acids into protein by a rat liver microsome-pH 5
Studies on the enzymatic reduction of C-nitroso compounds. IV. Partial purification and kinetic properties of porcine heart C-nitrosoreductase.
An NAD(P)H-dependent C-nitrosoreductase was purified 90 fold from porcine heart cytosol fraction by ammonium sulfate fractionation, gel filtration with Sephadex G-100, ion-exchange chromatography on