Bioassay for A-56268 (TE-031) and identification of its major metabolite, 14-hydroxy-6-O-methyl erythromycin

@article{Fernandes1988BioassayFA,
  title={Bioassay for A-56268 (TE-031) and identification of its major metabolite, 14-hydroxy-6-O-methyl erythromycin},
  author={Prabhavathi B Fernandes and Nancy C Ramer and Richard A Rode and Lilian Freiberg},
  journal={European Journal of Clinical Microbiology and Infectious Diseases},
  year={1988},
  volume={7},
  pages={73-76}
}
A-56268 is a new macrolide which is generally two-fold more potent than erythromycin. A new bioassay is described in which plasma samples are extracted with acetonitrile prior to bioassay. The concentration range for the assay is between 0.05–4.0 µg/ml, and the concentrations measured are within 6% of those measured by high-power liquid chromatography. An active metabolite which is as active as erythromycin was identified in the plasma. The plasma half-life and area under the plasma curve… CONTINUE READING

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The maero~ide Ievival: 35 years after erythromycin

  • P. B. Fernandes
  • Anfimicrobic Newsletter 1987,
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