Bioanalytical solutions to acetonitrile shortages.

  title={Bioanalytical solutions to acetonitrile shortages.},
  author={Hong Gao and John S Williams and Scott Carrier and Christopher L. Brummel},
  volume={2 9},
The acetonitrile shortage during 2008 to 2009 challenged bioanalytical scientists due to the ubiquitous role that acetonitrile plays in sample preparation and analysis. Replacement, reduction and reuse of acetonitrile were the core tenants behind each approach used to tackle the shortage. Sample preparation of biological matrices can be accomplished by protein precipitation using a variety of solvents; methanol is usually the best substitute for acetonitrile. The potential liabilities in using… CONTINUE READING


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