Bioanalytical procedures for determination of drugs of abuse in blood

@article{Kraemer2007BioanalyticalPF,
  title={Bioanalytical procedures for determination of drugs of abuse in blood},
  author={Thomas Kraemer and Liane D. Paul},
  journal={Analytical and Bioanalytical Chemistry},
  year={2007},
  volume={388},
  pages={1415-1435}
}
  • T. Kraemer, L. D. Paul
  • Published 28 April 2007
  • Chemistry, Medicine
  • Analytical and Bioanalytical Chemistry
Determination of drugs of abuse in blood is of great importance in clinical and forensic toxicology. This review describes procedures for detection of the following drugs of abuse and their metabolites in whole blood, plasma or serum: Δ9-tetrahydrocannabinol, 11-hydroxy-Δ9-tetrahydrocannabinol, 11-nor-9-carboxy-Δ9-tetrahydrocannabinol, 11-nor-9-carboxy-Δ9-tetrahydrocannabinol glucuronide, heroin, 6-monoacetylmorphine, morphine, morphine-6-glucuronide, morphine-3-glucuronide, codeine… Expand
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A modified version of this method that incorporates solid-phase extraction to further enhance sensitivity is presented and is sufficiently sensitive to directly quantify 18 analytes in wastewater at concentrations less than 50 ng/L. Expand
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The LC-MS/MS method provides a simple, specific, and sensitive solution for the quantification of some of the most frequent drugs of abuse and their metabolites in whole blood and was successfully applied to 412 forensic cases from October 2008 to mid February 2009. Expand
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The method was used to determine cocaine, benzoylecgonine, cocaethylene and AEME in 22 blood samples collected from victims of sudden, unexpected or violent death in Sao Paulo (Brazil) and showed that the method is precise, accurate, robust and sensitive for its purposes. Expand
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An ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) method for screening of drugs in whole blood has been developed and validated and recoveries from whole blood were > 50% except for morphine and THC. Expand
Paper spray and extraction spray mass spectrometry for the direct and simultaneous quantification of eight drugs of abuse in whole blood.
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Determination of eight drugs of abuse in blood has been performed using paper spray or extraction spray mass spectrometry in under 2 min with minimal sample preparation and exhibit the potential for performing rapid and high-throughput assays for selective on-site multicompound quantitative screening of illicit drugs. Expand
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The developed gas chromatography-mass spectrometric method proved capable of quantifying all three classes of drugs of abuse proposed in this study, through a one-step extraction procedure. Expand
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The methods were fully validated and proved to be suitable for analysis of 124 cocaine and/or crack cocaine users, showing the facility of accumulation in chronic users in matrices with a large detection window. Expand
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An immunoassay was established which enables a reliable quantification of serological drug samples and a sensitive and selective detection was possible, even in the presence of up to 9 drugs or of various anti-drug antibodies. Expand
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A confirmatory method for the determination of illicit drugs based on micro-solid phase extraction with modified tips, made of a functionalized fiberglass with apolar chains of octadecylsilane into… Expand
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