Bioanalytical procedures for determination of drugs of abuse in blood

@article{Kraemer2007BioanalyticalPF,
  title={Bioanalytical procedures for determination of drugs of abuse in blood},
  author={Thomas Kraemer and Liane D. Paul},
  journal={Analytical and Bioanalytical Chemistry},
  year={2007},
  volume={388},
  pages={1415-1435}
}
  • T. KraemerL. D. Paul
  • Published 28 April 2007
  • Biology, Chemistry
  • Analytical and Bioanalytical Chemistry
Determination of drugs of abuse in blood is of great importance in clinical and forensic toxicology. This review describes procedures for detection of the following drugs of abuse and their metabolites in whole blood, plasma or serum: Δ9-tetrahydrocannabinol, 11-hydroxy-Δ9-tetrahydrocannabinol, 11-nor-9-carboxy-Δ9-tetrahydrocannabinol, 11-nor-9-carboxy-Δ9-tetrahydrocannabinol glucuronide, heroin, 6-monoacetylmorphine, morphine, morphine-6-glucuronide, morphine-3-glucuronide, codeine… 
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102 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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102 Citations

Economical Synthesis of 13C-Labeled Opiates, Cocaine Derivatives and Selected Urinary Metabolites by Derivatization of the Natural Products

The synthetic work has focused on identifying 13C atom-efficient routes towards these derivatives, and the 13C-labeled opiates and cocaine derivatives were made from the corresponding natural products.

Quantification of drugs of abuse in municipal wastewater via SPE and direct injection liquid chromatography mass spectrometry

A modified version of this method that incorporates solid-phase extraction to further enhance sensitivity is presented and is sufficiently sensitive to directly quantify 18 analytes in wastewater at concentrations less than 50 ng/L.

Determination of 19 drugs of abuse and metabolites in whole blood by high-performance liquid chromatography–tandem mass spectrometry

The LC-MS/MS method provides a simple, specific, and sensitive solution for the quantification of some of the most frequent drugs of abuse and their metabolites in whole blood and was successfully applied to 412 forensic cases from October 2008 to mid February 2009.

Determination of cocaine, metabolites and a crack cocaine biomarker in whole blood by liquid-liquid extraction and UHPLC-MS/MS.

Drug screening of whole blood by ultra-performance liquid chromatography-tandem mass spectrometry.

An ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) method for screening of drugs in whole blood has been developed and validated and recoveries from whole blood were > 50% except for morphine and THC.

Paper spray and extraction spray mass spectrometry for the direct and simultaneous quantification of eight drugs of abuse in whole blood.

Determination of eight drugs of abuse in blood has been performed using paper spray or extraction spray mass spectrometry in under 2 min with minimal sample preparation and exhibit the potential for performing rapid and high-throughput assays for selective on-site multicompound quantitative screening of illicit drugs.

A one-step extraction procedure for the screening of cocaine, amphetamines and cannabinoids in postmortem blood samples.

The developed gas chromatography-mass spectrometric method proved capable of quantifying all three classes of drugs of abuse proposed in this study, through a one-step extraction procedure.

Simultaneous determination of cocaine/crack and its metabolites in oral fluid, urine and plasma by liquid chromatography-mass spectrometry and its application in drug users.

A novel immunoassay for quantitative drug abuse screening in serum.

Micro-solid phase extraction coupled with high-performance liquid chromatography-tandem mass spectrometry for the determination of stimulants, hallucinogens, ketamine and phencyclidine in oral fluids.

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