Bioanalytical procedures for determination of drugs of abuse in blood

@article{Kraemer2007BioanalyticalPF,
  title={Bioanalytical procedures for determination of drugs of abuse in blood},
  author={Thomas Kraemer and Liane D. Paul},
  journal={Analytical and Bioanalytical Chemistry},
  year={2007},
  volume={388},
  pages={1415-1435}
}
  • T. KraemerL. D. Paul
  • Published 28 April 2007
  • Biology, Chemistry
  • Analytical and Bioanalytical Chemistry
Determination of drugs of abuse in blood is of great importance in clinical and forensic toxicology. This review describes procedures for detection of the following drugs of abuse and their metabolites in whole blood, plasma or serum: Δ9-tetrahydrocannabinol, 11-hydroxy-Δ9-tetrahydrocannabinol, 11-nor-9-carboxy-Δ9-tetrahydrocannabinol, 11-nor-9-carboxy-Δ9-tetrahydrocannabinol glucuronide, heroin, 6-monoacetylmorphine, morphine, morphine-6-glucuronide, morphine-3-glucuronide, codeine… 

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Quantification of drugs of abuse in municipal wastewater via SPE and direct injection liquid chromatography mass spectrometry

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The LC-MS/MS method provides a simple, specific, and sensitive solution for the quantification of some of the most frequent drugs of abuse and their metabolites in whole blood and was successfully applied to 412 forensic cases from October 2008 to mid February 2009.

Drug screening of whole blood by ultra-performance liquid chromatography-tandem mass spectrometry.

An ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) method for screening of drugs in whole blood has been developed and validated and recoveries from whole blood were > 50% except for morphine and THC.

Paper spray and extraction spray mass spectrometry for the direct and simultaneous quantification of eight drugs of abuse in whole blood.

Determination of eight drugs of abuse in blood has been performed using paper spray or extraction spray mass spectrometry in under 2 min with minimal sample preparation and exhibit the potential for performing rapid and high-throughput assays for selective on-site multicompound quantitative screening of illicit drugs.

A one-step extraction procedure for the screening of cocaine, amphetamines and cannabinoids in postmortem blood samples.

The developed gas chromatography-mass spectrometric method proved capable of quantifying all three classes of drugs of abuse proposed in this study, through a one-step extraction procedure.
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