Bioanalytical Method Development , Validation and Quantification of Metaxalone by Liquid Chromatography Tandem Mass Spectrometry in Rat Plasma

Abstract

A simple, highly sensitive, precise and accurate high-performance liquid chromatographic (LCMSMS) method with mass detection was developed and validated for the rapid quantiication of metaxalone (CAS Registry No, 1665-481) in rat plasma samples. The chromatographic separation was achieved with a reverse phase column Agilent XDB C18 (4.6×100 mm, 5μ) and the… (More)

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