Bioanalysis of siRNA and oligonucleotide therapeutics in biological fluids and tissues.

@article{Tremblay2009BioanalysisOS,
  title={Bioanalysis of siRNA and oligonucleotide therapeutics in biological fluids and tissues.},
  author={Guy A Tremblay and Philip R Oldfield},
  journal={Bioanalysis},
  year={2009},
  volume={1 3},
  pages={595-609}
}
This article summarizes bioanalytical avenues for the determination of siRNA and oligonucleotide therapeutics, with an emphasis on hybridization methods. Aspects of the chemistry and delivery of investigational oligonucleotide therapeutics are considered. The nature of the oligonucleotide under investigation will dictate the best analytical course of action; each method has its advantages and disadvantages, depending upon the oligonucleotide test article and the anticipated toxicokinetic and… CONTINUE READING
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