Bioanalysis of antibody-drug conjugates: American Association of Pharmaceutical Scientists Antibody-Drug Conjugate Working Group position paper.

@article{Gorovits2013BioanalysisOA,
  title={Bioanalysis of antibody-drug conjugates: American Association of Pharmaceutical Scientists Antibody-Drug Conjugate Working Group position paper.},
  author={Boris Gorovits and Stephen C. Alley and Sanela Bilic and Brian Booth and Surinder Kaur and Phillip Oldfield and Shobha Purushothama and Chetana Rao and Stacy S. Shord and Patricia Siguenza},
  journal={Bioanalysis},
  year={2013},
  volume={5 9},
  pages={
          997-1006
        }
}
Antibody-drug conjugates (ADCs) typically consist of a cytotoxic drug covalently bound to an antibody by a linker. These conjugates have the potential to substantially improve efficacy and reduce toxicity compared with cytotoxic small-molecule drugs. Since ADCs are generally complex heterogeneous mixtures of multiple species, these novel therapeutic products present unique bioanalytical challenges. The growing number of ADCs being developed across the industry suggests the need for alignment of… CONTINUE READING

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