Bioalkylation of dibenz[a,b]anthracene in rat liver cytosol.

@article{Flesher1986BioalkylationOD,
  title={Bioalkylation of dibenz[a,b]anthracene in rat liver cytosol.},
  author={James W. Flesher and Steven R. Myers and Conrad H. Bergo and J. W. Blake},
  journal={Chemico-biological interactions},
  year={1986},
  volume={57 2},
  pages={
          223-33
        }
}
Previous studies by other investigators have established that L-region methyl derivatives of dibenz[a,h]anthracene (DBA) were more carcinogenic than the parent hydrocarbon. The bioalkylation of DBA was investigated by incubating the hydrocarbon with rat liver cytosol fortified with S-adenosyl-L-methionine (SAM) in 0.1 M phosphate buffer (pH 7.4) for 1 h at 37 degrees C in air. The reaction was stopped by the addition of cold acetone and the mixture extracted with ethyl acetate and washed with… Expand
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