Bioadhesive properties and rheology of polyether-modified poly(acrylic acid) hydrogels.

@article{Bromberg2004BioadhesivePA,
  title={Bioadhesive properties and rheology of polyether-modified poly(acrylic acid) hydrogels.},
  author={Lev Bromberg and Marina Temchenko and Valery Alakhov and T Alan Hatton},
  journal={International journal of pharmaceutics},
  year={2004},
  volume={282 1-2},
  pages={45-60}
}
Transient rheological properties and mucoadhesion of hydrogels composed of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO, or Pluronic) block copolymers and poly(acrylic acid) were explored. Nine Pluronic copolymers ranging in nominal molecular weight and PPO/PEO content were grafted to PAA through C-C bonds, with or without the use of divinyl cross-linker, ethylene glycol dimethacrylate (EGDMA). The hydrogel elasticity increased with the PPO content in the… CONTINUE READING