Bioadhesive monolayer film for the in vitro transdermal delivery of sumatriptan.

@article{FemenaFont2006BioadhesiveMF,
  title={Bioadhesive monolayer film for the in vitro transdermal delivery of sumatriptan.},
  author={Andr{\'e}s Femen{\'i}a-Font and Cristina Padula and Fabio Marra and Cristina Balaguer-Fern{\'a}ndez and V. Baonza Merino and Alicia C L{\'o}pez-Castellano and Sara Nicoli and Patrizia Santi},
  journal={Journal of pharmaceutical sciences},
  year={2006},
  volume={95 7},
  pages={1561-9}
}
The work presented here aims to develop a bioadhesive monolayer film containing sumatriptan as adjuvant for the treatment of headache pain in a severe migraine attack. Permeation experiments were performed from the films prepared and from the respective solution, to evaluate the relevant permeation parameters. The effect of the penetration enhancers Transcutol, 2-pyrrolidone, and polyethylene glycol 600 was evaluated. The results obtained show that Transcutol and 2-pyrrolidone decreased… CONTINUE READING

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