Bioadhesive emulsions for control release of progesterone resistant to vaginal fluids clearance.

@article{CampaaSeoane2014BioadhesiveEF,
  title={Bioadhesive emulsions for control release of progesterone resistant to vaginal fluids clearance.},
  author={Maria Campa{\~n}a-Seoane and Aaron Peleteiro and Reyes Laguna and Francisco-Javier Otero-Espinar},
  journal={International journal of pharmaceutics},
  year={2014},
  volume={477 1-2},
  pages={495-505}
}
The aim of this study is to propose that mucoadhesive vaginal emulsions can be able to resist the clearance effect of vaginal fluid and to have an effective control release of progesterone. With this goal, silicon derivative, cyclomethicone pentamer, was selected as the bioadhesive and water resistant material. In order to obtain a system which is insensitive to the dilution of aqueous fluids, water in silicone (W/S) emulsions were prepared and different proportions of cyclomethicone as well as… CONTINUE READING