Bioadhesive and histotoxic properties of ethyl-2-cyanoacrylate.

  title={Bioadhesive and histotoxic properties of ethyl-2-cyanoacrylate.},
  author={B J Zumpano and L. R. Costello J. D. MacDonald K. A. Jacobs and John Battaile Hall and G L Margolis and Ernest Sachs},
  journal={Surgical neurology},
  volume={18 6},
Ethyl-2-cyanoacrylate was applied to the cortex of rabbits to evaluate its bioadhesive and histotoxic behavior. The animals were killed at 4 or 10 days. Half of the animals were pretreated with dexamethasone. Our results indicate that the application of ethyl-2-cyanoacrylate to brain tissue produced severe superficial cortical necrosis but not bioadhesion. Pretreatment with steroids did not provide a significant protective effect.