Bioadhesion and oral absorption of enoxaparin nanocomplexes.

  title={Bioadhesion and oral absorption of enoxaparin nanocomplexes.},
  author={Wei Sun and Shirui Mao and Yanjun Wang and Varaporn Buraphacheep Junyaprasert and Tingting Zhang and Lidong Na and Juan Wang},
  journal={International journal of pharmaceutics},
  volume={386 1-2},
Polyelectrolyte complexes (PEC) formed between chitosan derivatives and enoxaparin were prepared by a self-assembly process and were characterized in terms of particle size and surface charge. The morphology was observed by atomic force microscopy (AFM). The colloidal stability and bioadhesion of the PEC were characterized by dynamic light scattering (DLS). The absorption of enoxaparin in rats was evaluated by activated partial thromboplastin time (APTT) assay. It was shown that the prepared… CONTINUE READING


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