Bioactivity profiling using HPLC/microtiter-plate analysis: application to a New Zealand marine alga-derived fungus, Gliocladium sp.

@article{Lang2006BioactivityPU,
  title={Bioactivity profiling using HPLC/microtiter-plate analysis: application to a New Zealand marine alga-derived fungus, Gliocladium sp.},
  author={Gerhard Lang and Maya I. Mitova and Gill Ellis and Sonia A van der Sar and Richard Kerry Phipps and John W Blunt and Nicholas J. Cummings and Anthony L. J. Cole and Murray H. G. Munro},
  journal={Journal of natural products},
  year={2006},
  volume={69 4},
  pages={
          621-4
        }
}
Using HPLC/microtiter-plate-based generation of activity profiles the extract of a marine alga-derived fungus, identified as Gliocladium sp., was shown to contain the known strongly cytotoxic metabolite 4-keto-clonostachydiol (1) and also clonostachydiol (2) as well as gliotide (3), a new cyclodepsipeptide containing several D-amino acids. The absolute configuration of 1 was elucidated by reduction to 2, and two further oxidized derivatives of clonostachydiol (5, 6) were prepared and evaluated… CONTINUE READING

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