Bioactivity of dietary polyphenols: The role of metabolites

  title={Bioactivity of dietary polyphenols: The role of metabolites},
  author={Simon Vlad Luca and Irina Macovei and Alexandra Bujor and Anca Miron and Krystyna Skalicka‐Woźniak and Ana Clara Aprotosoaie and Adriana Trifan},
  journal={Critical Reviews in Food Science and Nutrition},
  pages={626 - 659}
  • S. Luca, I. Macovei, A. Trifan
  • Published 21 February 2020
  • Biology, Chemistry
  • Critical Reviews in Food Science and Nutrition
Abstract A polyphenol-rich diet protects against chronic pathologies by modulating numerous physiological processes, such as cellular redox potential, enzymatic activity, cell proliferation and signaling transduction pathways. However, polyphenols have a low oral bioavailability mainly due to an extensive biotransformation mediated by phase I and phase II reactions in enterocytes and liver but also by gut microbiota. Despite low oral bioavailability, most polyphenols proved significant… 
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