Bioactivity of dietary polyphenols: The role of metabolites

@article{Luca2019BioactivityOD,
  title={Bioactivity of dietary polyphenols: The role of metabolites},
  author={S. Luca and Irina Macovei and Alexandra Bujor and A. Miron and K. Skalicka-Woźniak and A. C. Aprotosoaie and A. Trifan},
  journal={Critical Reviews in Food Science and Nutrition},
  year={2019},
  volume={60},
  pages={626 - 659}
}
Abstract A polyphenol-rich diet protects against chronic pathologies by modulating numerous physiological processes, such as cellular redox potential, enzymatic activity, cell proliferation and signaling transduction pathways. However, polyphenols have a low oral bioavailability mainly due to an extensive biotransformation mediated by phase I and phase II reactions in enterocytes and liver but also by gut microbiota. Despite low oral bioavailability, most polyphenols proved significant… Expand
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