Bioactivity-guided isolation of anticancer agents from Bauhinia kockiana Korth.

@article{Chew2014BioactivityguidedIO,
  title={Bioactivity-guided isolation of anticancer agents from Bauhinia kockiana Korth.},
  author={Yik-Ling Chew and Yau Yan Lim and Johnson Stanslas and Gwendoline Cheng Lian Ee and Joo Kheng Goh},
  journal={African journal of traditional, complementary, and alternative medicines : AJTCAM},
  year={2014},
  volume={11 3},
  pages={
          291-9
        }
}
  • Yik-Ling ChewY. Lim J. Goh
  • Published 29 March 2014
  • Biology, Chemistry
  • African journal of traditional, complementary, and alternative medicines : AJTCAM
BACKGROUND Flowers of Bauhinia kockiana were investigated for their anticancer properties. METHODS Gallic acid (1), and methyl gallate (2), were isolated via bioassay-directed isolation, and they exhibited anticancer properties towards several cancer cell lines, examined using MTT cell viability assay. Pyrogallol (3) was examined against the same cancer cell lines to deduce the bioactive functional group of the phenolic compounds. RESULTS The results showed that the phenolic compounds could… 

Figures and Tables from this paper

Phytochemical and anti-cancer properties of Euphorbia hierosolymitana Boiss. crude extracts

The selective differential in anti-cancer activity between different types of extracts is attractive and holds significant promise for the development of new cancer therapies.

Isolation And Characterization Of Flavonoid From Leaves Of Bauhinia kockiana Lour And Antibacterial Activity

The Isolation and purification of flavonoid compounds from the leaves of Bauhinia kockiana Lour had been done. Concentrated methanol extract was hydrolyzed with HCl 6%, partitioned with chloroform

Apoptosis Effects of Dihydrokaempferol Isolated from Bauhinia championii on Synoviocytes

Findings indicate that dihydrokaempferol isolated from the ethyl acetate extract of B. championii effectively promotes apoptosis, which is an important process through suppression of apoptotic activity.

Anti-methicillin-resistance Staphylococcus aureus (MRSA) compounds from Bauhinia kockiana Korth. And their mechanism of antibacterial activity

Tannins and polyphenols are the antibacterial components towards MRSA in B. kockiana, and massive leakage of the cell content observed in treated cells showed that the phytochemicals have changed the properties of thecell membranes.

Allium porrum and Bauhinia Variegata Mitigate Acute Liver Failure and Nephrotoxicity Induced by Thioacetamide in Male Rats

Treatment with Allium porrum and Bauhinia variegata extracts and their combination reduced deleterious effects of TAA on liver through antioxidant and anti-inflammatory properties.

Mounting Insights over Human Wellness by Utilizing Plant's Primed Defense against Precise/ Mild Oxidative Stress

The purpose of this paper is to examine the potential effects of precise/mild stress to improve nutritional quality and stress tolerance of crop plants and consequently on health and well-being of neighbors such as human.

Effect of methanolic extract of Maytenus procumbens and Ozoroa paniculosa on testicular dysfunction

A dissertation submitted to the Faculty of Science and Agriculture in fulfillment of the requirements for the Degree of Masters Of Science (MSc) in the Department of Biochemistry and Microbiology at

ID7 Isolated from Bauhinia variegata Stem Inhibits Tumor Progression and Metastatic Mechanisms of Triple Negative Breast Cancer in Vivo

It was found that ID7 fraction exhibits selective antitumor and on the mechanisms of breast cancer metastasis activity, preventing lung metastasis and inflammation in the liver.

References

SHOWING 1-10 OF 33 REFERENCES

Selective induction of cell death in cancer cells by gallic acid.

Three adjacent phenolic hydroxyl groups of gallic acid were responsible for the cytotoxicity, and the carboxyl group was not responsible, but seemed to be implicated in distinguishing between normal cells and cancer cells.

Influence of anthocyanins, derivative pigments and other catechol and pyrogallol-type phenolics on breast cancer cell proliferation.

Results point to the ortho trihydroxylated moiety in the phenolic ring as an important structural feature for more potent cytotoxicity effect on MCF-7 cells comparatively to the effect observed with the similar dihydroxYLated compounds.

Different generation of inhibitors against gallic acid-induced apoptosis produces different sensitivity to gallic acid.

The results suggest that the generation of a large amount of the inhibitor may endow hepatocytes with insensitivity to gallic acid, and should contribute to the underlying mechanism in the difference in sensitivity of cells togallic acid.

Studies on the chemical constituents and anticancer activity of Saxifraga stolonifera (L) Meeb.

Differentiation- and apoptosis-inducing activities by pentacyclic triterpenes on a mouse melanoma cell line.

It is suggested that the carbonyl group at C-17 might be essential for the apoptotic effects of these compounds on B16 2F2 cells.

Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells.

GA is identified as one of the major active constituents in GSE, with significant growth inhibition and apoptosis with the highest activity present in the later fractions that contained procyanidin trimers and GA esters of dimers and trimers.

Tannins and Flavonoids from the Erodium cicutarium Herb

A new depside, erodiol, was isolated and identified from the aerial parts of Erodium cicutarium (Geraniaceae), together with essential compounds such as: geraniin, didehydrogeraniin, corilagin, (-)

Structure-activity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1 in cell culture.

A putative binding mode of styrylquinoline inhibitors to HIV-1 IN was derived from literature data and SARs developed in this work, and the structural requirements for activity are more stringent than for in vitro inhibition.