Bioactive transforming growth factor-beta in the lungs of extremely low birthweight neonates predicts the need for home oxygen supplementation.

@article{Lecart2000BioactiveTG,
  title={Bioactive transforming growth factor-beta in the lungs of extremely low birthweight neonates predicts the need for home oxygen supplementation.},
  author={Chantal Lecart and Rowena G Cayabyab and Sue Buckley and John Morrison and Kenny Y-C Kwong and David Warburton and Rangasamy Ramanathan and Craig A. Jones and Parviz Minoo},
  journal={Biology of the neonate},
  year={2000},
  volume={77 4},
  pages={217-23}
}
Transforming growth factor-beta (TGF-beta) is a peptide implicated in tissue injury and repair but its role in the premature human lung remains unclear. In the present study, we used a TGF-beta responsive-promoter-luciferase construct in mink lung epithelial cells to quantify levels of biologically active TGF-beta (BA-TGF-beta) in the endotracheal aspirate (ETA) fluid from 16 extremely low birthweight neonates [6 M/10 F, mean GA 26 weeks (range 23-30), mean BW 774 g (range 555-1,075)]. ETA… CONTINUE READING

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