Bioactive scaffolds with enhanced supramolecular motion promote recovery from spinal cord injury

@article{lvarez2021BioactiveSW,
  title={Bioactive scaffolds with enhanced supramolecular motion promote recovery from spinal cord injury},
  author={Zaida {\'A}lvarez and A N Kolberg-Edelbrock and Ivan Ramos Sasselli and J. A. Ortega and R Qiu and Z Syrgiannis and Peter A. Mirau and F. Chen and Stacey M. Chin and S Weigand and Evangelos Kiskinis and Samuel I. Stupp},
  journal={Science},
  year={2021},
  volume={374},
  pages={848 - 856}
}
Description Fibril motion improves peptide signaling Artificial scaffolds that bear the peptide-signaling sequences of proteins for tissue regeneration often have limited effectiveness. Álvarez et al. synthesized supramolecular peptide fibril scaffolds bearing two peptide sequences that promote nerve regeneration, one that reduces glial scarring and another that promotes blood vessel formation (see the Perspective by Wojciechowski and Stevens). In a mouse model of paralyzing human spinal cord… 

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References

SHOWING 1-10 OF 45 REFERENCES

The Biology of Regeneration Failure and Success After Spinal Cord Injury.

The perineuronal net and how chondroitin sulfate proteoglycans deposited in both the glial scar and net impede axonal outgrowth at the level of the growth cone are discussed.

Mimicking the Bioactivity of Fibroblast Growth Factor-2 Using Supramolecular Nanoribbons

Results indicated the specificity of FGF2-PA nanoribbons in activating the FGF-2 signaling pathway and its potential application as a supramolecular scaffold that can be used in vivo as an alternative to the encapsulation and delivery of the native F GF-2 protein.

FGF-2-Responsive and Spinal Cord-Resident Cells Improve Locomotor Function after Spinal Cord Injury

The results argue for the continual use of autologous transplantation as a novel a novel treatment for axonal regeneration in rats.

Supramolecular Nanostructure Activates TrkB Receptor Signaling of Neuronal Cells by Mimicking Brain-Derived Neurotrophic Factor.

The incorporation of a BDNF mimetic sequence into a supramolecular peptide amphiphile filamentous nanostructure capable of activating the BDNF receptor TrkB and downstream signaling in primary cortical neurons in vitro is reported.

Required growth facilitators propel axon regeneration across complete spinal cord injury

Overcoming the failure of axon regrowth across anatomically complete SCI lesions after maturity required the combined sequential reinstatement of several developmentally essential mechanisms that facilitate axon growth.

Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke

It is demonstrated that genetic deletion of the neurite outgrowth inhibitor Nogo-A or one of its corresponding receptors, S1PR2, improves vascular sprouting and repair and reduces neurological deficits after cerebral ischemia in mice.

Tunable mechanics of peptide nanofiber gels.

The ability to modify how self- assembled fibrillar networks respond to deformations is important in developing self-assembled gels that can resist and recover from the large deformations that these gels encounter while serving as synthetic cell scaffolds in vivo.

β1-Integrin and Integrin Linked Kinase Regulate Astrocytic Differentiation of Neural Stem Cells

An important role for β1-integrin/ILK signaling in regulating astrogliosis from ESCs is demonstrated and ILK is suggested as a potential target for limiting glial scar formation after nervous system injury.

High-resolution 3D imaging and analysis of axon regeneration in unsectioned spinal cord with or without tissue clearing

This protocol can be used to elucidate the molecular and cellular mechanisms underlying nervous system degeneration and regeneration and to establish the therapeutic efficacy of candidate neuroregenerative treatments.