Bioactive saponins from Acacia tenuifolia from the suriname rainforest.

  title={Bioactive saponins from Acacia tenuifolia from the suriname rainforest.},
  author={Yong Sung Seo and Jeannine M Hoch and Maged Saad Abdel-Kader and Stan Malone and Iwan Derveld and Herbert G. Adams and Marga C. M. Werkhoven and Jan H. Wisse and Stephen W. Mamber and James M. Dalton and David G I Kingston},
  journal={Journal of natural products},
  volume={65 2},
Bioassay-guided fractionation of the MeOH extract of Acacia tenuifolia using the engineered yeast strains 1138, 1140, 1353, and Sc7 as the bioassay tool resulted in the isolation of the three new saponins 3, 5, and 6 and the three known saponins 1, 2, and 4. The structures of the new compounds were established on the basis of HRMS, 1D and 2D NMR spectral data on the intact saponins, and GC-MS analyses of the sugars. Compounds 1,2 and 5,6 showed cytotoxicity against mammalian cell lines.