Bioactive pyridoacridine alkaloids from the micronesian sponge Oceanapia sp.

@article{Eder1998BioactivePA,
  title={Bioactive pyridoacridine alkaloids from the micronesian sponge Oceanapia sp.},
  author={Claudia Eder and Peter E. Schupp and Peter Proksch and Victor Wray and Klaus Steube and Christa E. M{\"u}ller and Wolfgang Frobenius and Markus Herderich and Rob W. M. van Soest},
  journal={Journal of natural products},
  year={1998},
  volume={61 2},
  pages={301-5}
}
The Micronesian sponge Oceanapia sp. afforded three pyridoacridine alkaloids: the known compounds kuanoniamine C (1) and kuanoniamine D (2), as well as the new N-deacyl derivative (3) of the kuanoniamines. Compounds 1 and 2 exhibited insecticidal activity toward neonate larvae of the polyphagous pest insect Spodoptera littoralis (LC50 of 156 and 59 ppm, respectively), when incorporated into artificial diet. Both compounds also showed toxicity in the brine shrimp lethality test with a LC50 of 37… CONTINUE READING