Bioactive products from Okinawan marine micro- and macroorganisms

@article{Kobayashi2005BioactivePF,
  title={Bioactive products from Okinawan marine micro- and macroorganisms},
  author={J. Kobayashi and M. Tsuda},
  journal={Phytochemistry Reviews},
  year={2005},
  volume={3},
  pages={267-274}
}
New bioactive natural products have been recently isolated from marine dinoflagellates, marine-derived fungi, marine sponges, and tunicates. AmphidinolidesG (1), H (2), X (3), and Y (4) are cytotoxicmacrocyclicmetabolites separated from marine dinoflagellates Amphidinium sp. Speradine A (5), modiolides A (7) andB (8), sculezonones A (9) and B (10), seragakinone A (11), dictyonamides A (12) and B (13), and sporiolides A (14) and B (15) are secondary metabolites obtained from marine-derived fungi… Expand
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Amphidinolide X (1) is the first macrodiolide consisting of polyketide-derived diacid and diol units from natural sources, and the biosynthetic origins of 1 were investigated by means of feeding experiments with (13)C-labeled acetates. Expand
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A novel cytotoxic 17-membered macrolide, amphidinolide Y (1), has been isolated from a marine dinoflagellate Amphidinium sp., and it was elucidated to exist as a 9:1 equilibrium mixture of 6-keto-Expand
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Two new 10-membered macrolides and a new linear pentaketide, modiolin, were isolated from the cultured broth of a fungus Paraphaeosphaeria sp. Expand
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Two new metabolites possessing a phenalenone skeleton were isolated from cultured broth of the fungus Penicillium sp. Expand
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