Bioactive principles from the roots of Lindera megaphylla.

  title={Bioactive principles from the roots of Lindera megaphylla.},
  author={C. C. Chen and Yuan Li Huang and Jian Chih Ou and M. Jai Su and Sung-tsai Yu and C. M. Teng},
  journal={Planta medica},
  volume={57 5},
d-Dicentrine was isolated from the root of Lindera megaphylla. It inhibited the aggregation of washed rabbit platelets induced by ADP, collagen, arachidonic acid, and PAF. It also inhibited the high potassium- and norepinephrine-induced contraction of rat thoracic aorta. In rat ventricular cells treated with 3 microM d-dicentrine, the action potential duration (ADP50) was prolonged from 59.9 +/- 11.3 msec to 201 +/- 28.7 msec.