Bioactive molecules from the Blue Lagoon: in vitro and in vivo assessment of silica mud and microalgae extracts for their effects on skin barrier function and prevention of skin ageing

  title={Bioactive molecules from the Blue Lagoon: in vitro and in vivo assessment of silica mud and microalgae extracts for their effects on skin barrier function and prevention of skin ageing},
  author={S Grether-Beck and K M{\"u}hlberg and Heidi Brenden and Ingo Felsner and {\'A}sa Brynj{\'o}lfsd{\'o}ttir and Sigurbjorn Einarsson and Jean Krutmann},
  journal={Experimental Dermatology},
Bathing in the Blue Lagoon, a specific geothermal biotope in Iceland has been known for many years to be beneficial for human skin in general and for patients with psoriasis and atopic dermatitis in particular. [] Key Result The same extracts also affects primary human dermal fibroblasts, because extracts from silica mud and one type of algae inhibited UVA radiation-induced upregulation of matrix metalloproteinase-1 expression and both algae, as well as silica mud extracts induced collagen 1A1 and 1A2 gene…
Blue Lagoon Algae Improve Uneven Skin Pigmentation: Results from in vitro Studies and from a Monocentric, Randomized, Double-Blind, Vehicle-Controlled, Split-Face Study
BL algae can affect human melanocyte function in vitro and reduce uneven facial skin pigmentation in vivo, as well as benefit patients with psoriasis.
Anti-Inflammation Activities of Mycosporine-Like Amino Acids (MAAs) in Response to UV Radiation Suggest Potential Anti-Skin Aging Activity
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Treatment with Modified Extracts of the Microalga Planktochlorella nurekis Attenuates the Development of Stress-Induced Senescence in Human Skin Cells
It is postulate that selected microalgal extracts of Planktochlorella nurekis can be considered to be used in skin anti-aging therapy and reduced the development of oxidative stress-induced senescence in skin cells.
Extract of Ettlia sp. YC001 Exerts Photoprotective Effects against UVB Irradiation in Normal Human Dermal Fibroblasts.
The identification of novel reagents that exert a biological ultraviolet (UV)-protective effect in skin cells represents an important strategy for preventing UV-induced skin aging. To this end, we
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Phytochemical screening and in-vitro evaluation of Free Radical Scavenging Activity of Pistia stratiotes extracts
Medicinal plants have been identified and used throughout human history and many of the pharmaceuticals currently available to physicians have a long history of use as herbal remedies A large number
Modulation of skin pigmentation by the tetrapeptide PKEK: in vitro and in vivo evidence for skin whitening effects
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Anti-Inflammatory, Barrier-Protective, and Antiwrinkle Properties of Agastache rugosa Kuntze in Human Epidermal Keratinocytes
Findings preliminarily imply that the leaves of A. rugosa possess desirable cosmetic potentials, such as anti-inflammatory, barrier protective, and antiwrinkle activities, which infers their skin healing potentials.
Effect of the multifunctional cosmetic ingredient sphinganine on hair loss in males and females with diffuse hair reduction
In vitro results showed that sphinganine is a potent inhibitor of 5-α-reductase type I that prevents the conversion of testosterone to dihydrotestosterone, a key factor of androgenetic male baldness and well suited as a topical alternative for the improvement of scalp health and hair quality and anti-hair loss application.
Beneficial Effects of Marine Algae-Derived Carbohydrates for Skin Health
The present review focuses on the various biological capacities and potential skin health benefits of bioactive marine carbohydrates.


Dietary constituents are able to play a beneficial role in canine epidermal barrier function
It was found that a combination of pantothenate, choline, nicotinamide, histidine and inositol, when fed at supplemented concentrations, was able to significantly reduce TEWL in dogs after 9 weeks.
Green tea polyphenol induces caspase 14 in epidermal keratinocytes via MAPK pathways and reduces psoriasiform lesions in the flaky skin mouse model
Results indicate that the p38 and JNK MAPK pathways are required for EGCG‐induced expression of caspase 14 in NHEK and that GTP‐activated pathways may be potential targets for novel therapeutic approaches to the treatment of some psoriasiform skin disorders.
UVA irradiation induces collagenase in human dermal fibroblasts in vitro and in vivo
Collagen type I and Β-actin mRNA levels remained unaltered following irradiation, suggesting that the synthetic pathway of collagen metabolism at the pretranslational level is not affected by short-term UVA irradiation.
DNA damage in lung epithelial cells isolated from rats exposed to quartz: role of surface reactivity and neutrophilic inflammation.
Evidence is provided that modification of the particle surface prevents DNA strand breakage in epithelial lung cells from quartz-exposed rats and shows the feasibility of the in vivo model to evaluate the role of inflammation, antioxidant status, and cytotoxicity in particle-induced DNA damage.
Use of a serum-free epidermal culture model to show deleterious effects of epidermal growth factor on morphogenesis and differentiation.
The data illustrate that EGF cannot be considered a simple mitogen and underscore the importance of using sophisticated culture models to assess complex cytokine effects that may be dependent on the architecture of a differentiating epidermis.
New Developments in Photoprotection of Human Skin
Two examples are given to illustrate the development of a novel assay that is based on the detection of UVA-radiation-induced mutations in mitochondrial DNA and can be used to study the efficacy of protective measures against photoaging of human skin.
Sunscreens with an absorption maximum of > or =360 nm provide optimal protection against UVA1-induced expression of matrix metalloproteinase-1, interleukin-1, and interleukin-6 in human dermal fibroblasts.
It is indicated that UVA1 filters with a maximum absorption at > or =360 nm are most effective in preventing U VA1 radiation-induced MMP-1, IL-1alpha, and IL-6 expression pointing towards a critical role for effective filtering beyond > or=360 nm for protection against UVA 1-induced photoaging.