• Corpus ID: 12365539

Bioactive molecules from amphibian skin: their biological activities with reference to therapeutic potentials for possible drug development.

@article{Gomes2007BioactiveMF,
  title={Bioactive molecules from amphibian skin: their biological activities with reference to therapeutic potentials for possible drug development.},
  author={Antony Gomes and Biplab Giri and Archita Saha and R Mishra and Subir Chandra Dasgupta and Anindita Debnath and Aparna Gomes},
  journal={Indian journal of experimental biology},
  year={2007},
  volume={45 7},
  pages={
          579-93
        }
}
  • A. Gomes, B. Giri, A. Gomes
  • Published 1 July 2007
  • Biology, Chemistry
  • Indian journal of experimental biology
The amphibian skin contains various bioactive molecules (peptides, proteins, steroids, alkaloids, opiods) that possess potent therapeutic activities like antibacterial, antifungal, antiprotozoal, antidiabetic, antineoplastic, analgesic and sleep inducing properties. Research on amphibian skin derived biomolecules can provide potential clue towards newer drug development to combat various pathophysiological conditions. An overview on the bioactive molecules of various amphibian skins has been… 

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References

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TLDR
Six antimicrobial peptides, named gaegurins, were isolated from the skin of a Korean frog, Rana rugosa, and their amino acid sequences were determined by automated Edman degradation, providing the potential for application of these peptides to effective therapeutic agents for control of pathogenic microorganisms.

Temporins, Small Antimicrobial Peptides with Leishmanicidal Activity*

TLDR
The unique properties of temporins, as well as their membranolytic effect, which should make it difficult for the pathogen to develop resistance, suggest them as potential candidates for the future design of antiparasitic drugs with a new mode of action.

nNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications. The solution structure of a modified citropin 1.1.

TLDR
The structure-activity relationship of citropin 1.1 is investigated, indicating the terminal residues are important for bacterial activity and increasing the overall positive charge, while maintaining an amphipathic distribution of residues, increases activity against Gram-negative organisms.

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TLDR
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TLDR
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TLDR
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TLDR
Toad (Bufo melanostictus) skin a rich source of bioactive compounds, was explored for possible pharmacological effects on experimental animals and TSE did not possess haemorrhagic activity but produced strong haemolytic activity.
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