• Corpus ID: 12365539

Bioactive molecules from amphibian skin: their biological activities with reference to therapeutic potentials for possible drug development.

@article{Gomes2007BioactiveMF,
  title={Bioactive molecules from amphibian skin: their biological activities with reference to therapeutic potentials for possible drug development.},
  author={Antony Gomes and Biplab Giri and Archita Saha and R Mishra and Subir Chandra Dasgupta and Anindita Debnath and Aparna Gomes},
  journal={Indian journal of experimental biology},
  year={2007},
  volume={45 7},
  pages={
          579-93
        }
}
  • A. GomesB. Giri A. Gomes
  • Published 1 July 2007
  • Biology, Chemistry
  • Indian journal of experimental biology
The amphibian skin contains various bioactive molecules (peptides, proteins, steroids, alkaloids, opiods) that possess potent therapeutic activities like antibacterial, antifungal, antiprotozoal, antidiabetic, antineoplastic, analgesic and sleep inducing properties. Research on amphibian skin derived biomolecules can provide potential clue towards newer drug development to combat various pathophysiological conditions. An overview on the bioactive molecules of various amphibian skins has been… 

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References

SHOWING 1-10 OF 140 REFERENCES

Temporins, Small Antimicrobial Peptides with Leishmanicidal Activity*

The unique properties of temporins, as well as their membranolytic effect, which should make it difficult for the pathogen to develop resistance, suggest them as potential candidates for the future design of antiparasitic drugs with a new mode of action.

nNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications. The solution structure of a modified citropin 1.1.

The structure-activity relationship of citropin 1.1 is investigated, indicating the terminal residues are important for bacterial activity and increasing the overall positive charge, while maintaining an amphipathic distribution of residues, increases activity against Gram-negative organisms.

Antibacterial and hemolytic activity of the skin of the terrestrial salamander, Plethodon cinereus.

This study examines the skin from the tail region for the production of antimicrobial peptides in the terrestrial salamander, Plethodon cinereus, and finds antibacterial activity gradually increased over a 4-hr incubation time up to about 85% inhibition of bacterial growth.

Tigerinins: Novel Antimicrobial Peptides from the Indian FrogRana tigerina *

Tigerinins represent the smallest, nonhelical, cationic antimicrobial peptides from amphibians and are characterized by an intramolecular disulfide bridge between two cysteine residues forming a nonapeptide ring.

Pharmacological Study of the toad skin extract on experimental animals

Toad (Bufo melanostictus) skin a rich source of bioactive compounds, was explored for possible pharmacological effects on experimental animals and TSE did not possess haemorrhagic activity but produced strong haemolytic activity.

Isolation and characterization of novel antimicrobial peptides, rugosins A, B and C, from the skin of the frog, Rana rugosa.

Three antimicrobial peptides were isolated from the skin of Rana rugosa and one exhibited a striking antimicrobial activity against both gram-negative and gram-positive bacterial species.
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