Bioactive metabolites of EM574 and EM523, erythromycin derivatives having strong gastrointestinal motor stimulating activity.

Abstract

Two motilides, EM574 (N-demethyl-N-isopropyl-8,9-anhydroerythromycin A 6,9-hemiacetal) and EM523 (N-demethyl-N-ethyl-8,9-anhydroerythromycin A 6,9-hemiacetal) have strong gastrointestinal motor stimulating (GMS) activity. When administered orally to dogs, these agents showed strong GMS activity, but their plasma levels were very low and the metabolites… (More)

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Cite this paper

@article{Funabashi1996BioactiveMO, title={Bioactive metabolites of EM574 and EM523, erythromycin derivatives having strong gastrointestinal motor stimulating activity.}, author={Yasunori Funabashi and Yoshihiro Maeshiba and Nobuhiro Inatomi and S Tanayama and Shoji Harada and Zen Itoh and Satoshi O̅mura}, journal={The Journal of antibiotics}, year={1996}, volume={49 8}, pages={794-801} }