Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata.

  title={Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata.},
  author={Deniz Taşdemir and Gina C. Mangalindan and Gisela P. Concepcion and Sheryl M Verbitski and Sridhar Krishna Rabindran and Miriam Miranda and Michael Greenstein and John N A Hooper and Mary Kay Harper and Chris M. Ireland},
  journal={Journal of natural products},
  volume={65 2},
Two new isomalabaricane triterpenes, stellettin H (1) and stellettin I (2), have been isolated from the marine sponge Rhabdastrella globostellata, collected from the Philippines. Stellettins A-D (3-6), (-)-stellettin E (7), and rhabdastrellic acid-A (8) were also isolated and characterized. Stellettin B (4) and (-)-stellettin E (7) showed selective cytotoxicity toward p21(WAF1/Cip1)-deficient human colon tumor (HCT-116) cells with IC(50) values of 0.043 and 0.039 microM, respectively. 

Rhabdastrenones A–D from the sponge Rhabdastrella globostellata

Three new isomalabaricanes (1–3), a new α-pyrone derivative (4), together with four known isomalabaricane analogs rhabdastrellin G (5), isogeoditin A (6), stelliferin A (7), and (13E)-isogeoditin A

Isomalabaricane Triterpenes from the Marine Sponge Rhabdastrella sp.

These isolates were found to exhibit unique structural features with the only reported tetrahydrofuran functionality among all marine-derived isomalabaricanes.

Jaspiferin G, a new isomalabaricane-type triterpenoid from the sponge Jaspis stellifera

A new isomalabaricane-type triterpenoid, jaspiferin G, which was isolated from the marine sponge Jaspis stellifera and elucidated on the basis of spectroscopic data and mass spectrometry.

Cyclobutastellettolides A and B, C19 Norterpenoids from a Stelletta sp. Marine Sponge.

Two novel C19 terpenoids (1, 2) with an unprecedented carbon skeleton (A) were isolated from a Stelletta sp. sponge collected from Vietnamese waters. Their structures and absolute configurations were

Jaspiferins H–J, New Isomalabaricane-Type Terpenoids from the South China Sea Marine Sponge Jaspis stellifera

Three new isomalabaricane-type terpenoids, jaspiferins H (1), I (2), and J (3), were isolated from the marine sponge Jaspis stellifera collected from the South China Sea. The structures of the new