Bioactive isocoumarins isolated from the endophytic fungus Microdochium bolleyi.


Three new isocoumarin derivatives ( 2- 4) were isolated together with monocerin ( 1) from Microdochium bolleyi, an endophytic fungus from Fagonia cretica, a herbaceous plant of the semiarid coastal regions of Gomera. Compounds 2 and 3 are both 12-oxo epimers of 1, and 4 is a ring-opened derivative of 1. The structures were elucidated by detailed spectroscopic analysis and comparison with reported data. The absolute configurations were determined by a modified Mosher's method. Compounds 1, 3, and 4 showed good antifungal, antibacterial, and antialgal activities against Microbotryum violaceum, Escherichia coli, Bacillus megaterium, and Chlorella fusca. Compound 2 was moderately antifungal and antialgal.

DOI: 10.1021/np800095g
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@article{Zhang2008BioactiveII, title={Bioactive isocoumarins isolated from the endophytic fungus Microdochium bolleyi.}, author={Wen Zhang and Karsten Krohn and Siegfried Draeger and Barbara E Schulz}, journal={Journal of natural products}, year={2008}, volume={71 6}, pages={1078-81} }