Bioactive insulin-like growth factor-I in obesity.

@article{Frystyk2009BioactiveIG,
  title={Bioactive insulin-like growth factor-I in obesity.},
  author={Jan Frystyk and Danielle Jayne Brick and Anu V. Gerweck and Andrea L. Utz and Karen Klahr Miller},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2009},
  volume={94 8},
  pages={
          3093-7
        }
}
CONTEXT In obesity, total IGF-I is not reduced to the degree predicted by low GH levels, and free IGF-I levels are normal to high. Total and free IGF-I may not reflect IGF-I biological activity because immunoassays cannot account for the modifying effects of IGF binding proteins on interactions between IGF-I and its receptor. OBJECTIVE The aim of the study was to investigate the biological activity of IGF-I in obesity. DESIGN AND SETTING We conducted a cross-sectional study at a General… CONTINUE READING
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