Bioactive gold(i) complexes with 4-mercaptoproline derivatives.

  title={Bioactive gold(i) complexes with 4-mercaptoproline derivatives.},
  author={Alejandro Guti{\'e}rrez and Carlos Cativiela and A. Hern{\'a}ndez Laguna and M. Concepci{\'o}n Gimeno},
  journal={Dalton transactions},
  volume={45 34},
Unprecedented gold(i) bioconjugates bearing non-proteinogenic amino acid 4-mercaptoproline species as bioorganic ligands have been prepared. Firstly, the synthesis of Boc-Pro(SH)-OMe (1) has been accomplished by standard procedures. The subsequent reaction of 1 with [AuCl(PR3)] gives complexes Boc-Pro(SAuPR3)-OMe (PR3 = PPh3 (2), PPh2Py (3)). Starting from complex 2 several structural modifications have been performed, in addition to the incorporation of a different phosphine in 3, such as the… 
12 Citations
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