Bioactive cystine knot proteins.

Abstract

The cystine knot is a structural motif that confers exceptional stability on proteins. Here we provide an update on the topology of the cystine knot and the combinatorial diversity of proteins that contain it. We describe recent chemical biology studies that have utilised this structural motif for the development of potential therapeutic or diagnostic… (More)
DOI: 10.1016/j.cbpa.2011.02.008

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