Bioactive constituents of the roots of Licania intrapetiolaris.

  title={Bioactive constituents of the roots of Licania intrapetiolaris.},
  author={Nicholas H Oberlies and Jason Burgess and Hern{\'a}n A. Navarro and Rosa Elena Pinos and Djaja Djendoel Soejarto and N. R. Farnsworth and A Douglas Kinghorn and Mansukh C. Wani and Monroe E. Wall},
  journal={Journal of natural products},
  volume={64 4},
Fractionation of a methanol extract of the roots of Licania intrapetiolaris, as directed by activity against the KB assay, has led to the isolation of two novel clerodane diterpenoids, intrapetacins A (1) and B (2), and the known triterpenoid cucurbitacin B (3). The structures of 1 and 2 were deduced from one- and two-dimensional NMR experiments, including relative stereochemical assignments based on NOESY correlations and COSY coupling constants. Compound 3 was the most potent against the KB… CONTINUE READING