Bioactive cell-hydrogel microcapsules for cell-based drug delivery.

  title={Bioactive cell-hydrogel microcapsules for cell-based drug delivery.},
  author={Gorka Orive and Maria C. A. Brelaz. de Castro and Hyun-Joon Kong and Rosa M A Hern{\'a}ndez and Sara Ponce and David J Mooney and Jos{\'e} Luis Pedraz},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={135 3},
Improvement of long-term drug release and design of mechanically more stable encapsulation devices are still major challenges in the field of cell encapsulation. This may be in part due to the weak in vivo stability of calcium-alginate beads and to the use of inactive biomaterials and inert scaffolds that do not mimic the physiological situation of the normal cell milieu. We hypothesized that designing biomimetic cell-hydrogel capsules might promote the in vivo long-term functionality of the… CONTINUE READING
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