Bioactive analogs of neurotensin: focus on CNS effects.

  title={Bioactive analogs of neurotensin: focus on CNS effects.},
  author={Mona M Boules and Paul A Fredrickson and Elliott Richelson},
  volume={27 10},
Neurotensin (NT) is a 13-amino acid neuropeptide found in the central nervous system and in the gastrointestinal tract. It is closely associated anatomically with dopaminergic and other neurotransmitter systems, and evidence supports a role for NT agonists in the treatment of various neuropsychiatric disorders. However, NT is readily degraded by peptidases, so there is much interest in the development of stable NT agonists, that can be injected systemically, cross the blood-brain barrier (BBB… CONTINUE READING
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