Bioactive alkaloids from the plant endophytic fungus Aspergillus terreus.
@article{Ge2010BioactiveAF,
title={Bioactive alkaloids from the plant endophytic fungus Aspergillus terreus.},
author={Hui Ming Ge and Hui Peng and Zhi-kai Guo and Jiang Tao Cui and Yong Chun Song and Ren-Xiang Tan},
journal={Planta medica},
year={2010},
volume={76 8},
pages={
822-4
}
}One new alkaloid, named 16 alpha-hydroxy-5 N-acetylardeemin ( 1), along with seven known metabolites ( 2- 8) was isolated from the fermentation broth of an endophytic fungus, ASPERGILLUS TERREUS. The structures of these metabolites were assigned on the basis of detailed spectroscopic analysis and by comparing spectroscopic data with those in the literature. Compound 1 displayed an inhibitory effect against acetylcholinesterase. Compounds 1- 8 also showed moderate or weak cytotoxic activity…
34 Citations
Furandiones from an endophytic Aspergillus terreus residing in Malus halliana.
- ChemistryChemical & pharmaceutical bulletin
- 2012
Two new furandiones named asperterone B and C showed moderate cytotoxic activities against human colorectal carcinoma SW1116 cells with IC(50) values of 57.5 and 71.0 µM, respectively.
Fumigaclavine I, a new alkaloid isolated from endophyte Aspergillus terreus.
- Chemistry, BiologyChinese journal of natural medicines
- 2015
Two new alkaloids from a marine-derived fungus Neosartorya sp.HN-M-3
- ChemistryJournal of Asian natural products research
- 2012
Two new indole alkaloids, tryptoquivalines P and Q, have been isolated from a marine-derived fungus Neosartorya sp.HN-M-3 on the basis of spectroscopic methods.
Antiviral butyrolactones from the endophytic fungus Aspergillus versicolor.
- Chemistry, BiologyPlanta medica
- 2015
Compound 1 is the first naturally occurring butyrolactone possessing an unusual 2-oxopropyl group and showed moderate cytotoxicity against A549 and MCF7 cells with IC50 values of 3.2 and 2.5 µM, respectively.
Bioactive Potentials of Novel Molecules from the Endophytes of Medicinal Plants
- BiologyMicroorganisms for Sustainability
- 2019
Endophytes are microbial chemical factories more suited for the production of novel metabolites with therapeutic potentials, and approaches for the augmentation of metabolites and a special mention of the metabolites by Pestalotiopsis species are highlighted.
Bioactive Compounds of Endophytic Fungi Associated with Medicinal Plants
- BiologyRecent Advancement in White Biotechnology Through Fungi
- 2019
This chapter focused on compounds isolated from endophytic fungi recovered from medicinal plants that were evaluated for their antibacterial, antifungal, antiviral, trypanocidal and leishmanicidal, antitumor, antioxidant, and acetylcholinesterase inhibitor activities.
Metabolites with Insecticidal Activity from Aspergillus fumigatus JRJ111048 Isolated from Mangrove Plant Acrostichum specioum Endemic to Hainan Island
- BiologyMarine drugs
- 2017
The ethyl acetate extract of the fermentation broth of Aspergillus fumigatus JRJ111048, a fungus isolated from the leaves of the mangrove plant Acrostichum specioum endemic to Hainan island, was found to possess insecticidal activity against Spodoptera litura.
Alkaloidal metabolites from Aspergillus felis and their activities against Paracoccidioides brasiliensis
- Biology
- 2016
Sartoryglabrins, Analogs of Ardeemins, from Neosartorya Glabra
- Chemistry, BiologyNatural product communications
- 2011
Chemical investigation of a collection of the fungus Neosartorya glabra from Thailand furnished sartoryglabins A-C (1a, 1b and 2) which are analogs of the reverse prenylated indole alkaloids known as (-) ardeemins which exhibited strong to moderate activity against the MCF-7 cell line but weak or no action against the NCI-H460 and A375-C5 cell lines.
References
SHOWING 1-10 OF 15 REFERENCES
Bioactive alkaloids from endophytic Aspergillus fumigatus.
- Chemistry, BiologyJournal of natural products
- 2009
Two new alkaloids, named 9- deacetylfumigaclavine C and 9-deacetoxyfumigAClavineC, along with 12 known compounds, were isolated from the culture of Aspergillus fumigatus and showed selectively potent cytotoxicity against human leukemia cells.
Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp. IFB-E015.
- BiologyOrganic letters
- 2006
Chaetominine (1), an alkaloidal metabolite with a new framework, was characterized from the solid-substrate culture of Chaetomium sp. IFB-E015, an endophytic fungus on the apparently healthy…
5-N-acetylardeemin, a novel heterocyclic compound which reverses multiple drug resistance in tumor cells. I. Taxonomy and fermentation of the producing organism and biological activity.
- BiologyThe Journal of antibiotics
- 1993
The ardeemins are a new family of secondary metabolites produced by submerged fermentation of a fungus which was isolated from a soil sample collected in Brazil and potentiated the cytotoxicity of the anticancer agent vinblastine in multidrug resistant human tumor cells.
1H and 13C NMR assignments of two new indolic enamide diastereomers from a mangrove endophytic fungus Aspergillus sp.
- Chemistry, EngineeringMagnetic resonance in chemistry : MRC
- 2008
Terpeptin A (1) and B (2), two new members of the indolic enamides, along with three known compounds (3–5) were identified from a strain of Aspergillus sp. (w‐6), an endophytic fungus associated with…
Absolute configuration of new cytotoxic and other bioactive trichothecene macrolides.
- Chemistry, BiologyChemistry
- 2006
The absolute configuration of the reported bioactive analogue, mytoxin B was established by correlating its spectral data with that of known absolute configurational structures, and the significance in endophytism and biocatabolism, highlighted by production of those macrolides by the endophytic strains, is discussed in brief.
Cytotoxic benzo[j]fluoranthene metabolites from Hypoxylon truncatum IFB-18, an endophyte of Artemisia annua.
- ChemistryJournal of natural products
- 2007
Two new benzo[j]fluoranthene-based secondary metabolites named daldinone C and daldInone D (2) were isolated from the CHCl3/MeOH (1:1) extract of a solid culture of the endophyte Hypoxylon truncatum IFB-18 harbored inside the symptomless stem tissue of Artemisia annua and were substantially cytotoxic against SW1116 cells.
Hopeahainol A: an acetylcholinesterase inhibitor from Hopea hainanensis.
- ChemistryChemistry
- 2008
A phytochemical study of Hopea hainanensis has led to the isolation of three new polyphenols and one known compound. The most important of these compounds are hopeahainols A (2) and B (3), which…
Bioactive Alkaloids from the Sea: A Review
- Biology, ChemistryMarine Drugs
- 2004
The bioactive marine alkaloid Norzoanthamine hydrochloride, isolated from the colonial zoanthid Zoanthus sp.
Characterization of Mycotypha metabolites found to be inhibitors of cell adhesion molecules.
- Biology, ChemistryThe Journal of antibiotics
- 2002
Three inhibitors of cell adhesion based on LFA-1/ICAM-1 were isolated from the cultured broth of the fungal strain Mycotypha sp. UMF-006. These compounds were identified by spectroscopy to be…
Structure of rosellichalasin, a new metabolite produced by Rosellinia necatrix.
- Chemistry
- 1989
Isolation and structural elucidation of rosellichalasin produced by Rosellinia necatrix, with mass spectral analysis and NMR spectroscopy


