Bioactive acylphloroglucinols from Hypericum densiflorum

  title={Bioactive acylphloroglucinols from Hypericum densiflorum},
  author={Geneive E. Henry and Matthew S. Campbell and Ashlee A. Zelinsky and Yunbao Liu and Camile S Bowen-Forbes and Liya Li and Muraleedharan G. Nair and David C. Rowley and Navindra P. Seeram},
  journal={Phytotherapy Research},
Three acylphloroglucinol derivatives have been isolated from the hexane and acetone extracts of the aerial parts of Hypericum densiflorum Pursch. The compounds were characterized by NMR spectroscopy and mass spectrometry and identified as 4‐geranyloxy‐2,6‐dihydroxybenzophenone (1), 4‐geranyloxy‐1‐(2‐methylpropanoyl)‐ phloroglucinol (2) and 4‐geranyloxy‐1‐(2‐methylbutanoyl)‐phloroglucinol (3). Compounds 1–3 were evaluated for in vitro cell proliferation inhibitory activity against human breast… 
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Three new acylphloroglucinol derivatives have been isolated from the hexane extract of the aerial parts of Hypericum prolificum L.: prolificin A (1), prolifenone A (2), and prolifenone B (3). The
Are acylphloroglucinols lead structures for the treatment of degenerative diseases?
  • L. Verotta
  • Chemistry, Biology
    Phytochemistry Reviews
  • 2004
In recent years a widespread interest in the antidepressant activity of Hypericum perforatum L. has attracted much activity in investigating metabolites from the Guttiferae, many of which are biologically active compounds with an acylphloroglucinol moiety claimed to possess antioxidant, antiviral and antimitotic properties.
Impact of alkyl esters of caffeic and ferulic acids on tumor cell proliferation, cyclooxygenase enzyme, and lipid peroxidation.
A series of ferulic and caffeic acid esters were synthesized and tested for tumor cell proliferation, cyclooxygenase enzymes (COX-1 and -2) and lipid peroxidation inhibitory activities in vitro and some showed excellent growth inhibition of colon cancer cells.
Cytotoxic and antimicrobial benzophenones from the leaves of Tovomita longifolia.
Compounds 1 and 3-5 demonstrated cytotoxic activities against breast, central nervous system, and lung human cancer cell lines, while compounds 3-6 showed antimicrobial activity against Klebsiella pneumoniae, Mycobacterium smegmatis, Pseudomonas aeruginosa, Salmonella gallinarum, and Staphylococcus aureus.
Antibacterial and Cytotoxic Activity of Prenylated Bicyclic Acylphloroglucinol Derivatives from Hypericum amblycalyx
Four acylphloroglucinol derivatives isolated from the petroleum ether extract of the aerial parts of Hypericum amblycalyx showed moderate cytotoxic activity against KB and Jurkat T cancer cells and exhibited a strong antibacterial activity against different Gram-positive strains.
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Six new xanthones, cratoxyarborenones A-F (1-6), were isolated from the leaves, twigs, and/or stem bark of Cratoxylum sumatranum along with the known compound, vismione B (9), as active constituents
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Two new and four known phloroglucinol derivatives were isolated from the dichloromethane extract of the Greek endemic plant Hypericum jovis and demonstrated significant antioxidant activity, while two of them possessed activity at a cellular level comparable to Trolox, protecting against ROS.