Bioactive TGF-beta levels can be preserved in plasma samples collected into heparin but not EDTA.

@article{Walther2009BioactiveTL,
  title={Bioactive TGF-beta levels can be preserved in plasma samples collected into heparin but not EDTA.},
  author={Michael F Walther and Isatou K Jallow and Devair Jeffries and Brigitte Walther},
  journal={Cytokine},
  year={2009},
  volume={48 3},
  pages={
          267-72
        }
}
Quantifying TGF-beta is important for many research areas since its effects often are dose-dependently bidirectional. The post-transcriptional control of TGF-beta bioavailability points out the need to determine TGF-beta at the protein level. Studies measuring TGF-beta in peripheral blood have to avoid contamination with platelet-derived TGF-beta. Techniques to obtain platelet-poor plasma have been suggested, however, the impact of different anti-coagulants on artificial TGF-beta contamination… CONTINUE READING
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