Bioactive Secondary Metabolites from Octocoral-Associated Microbes—New Chances for Blue Growth

@article{Raimundo2018BioactiveSM,
  title={Bioactive Secondary Metabolites from Octocoral-Associated Microbes—New Chances for Blue Growth},
  author={I. Raimundo and Sandra Godinho Silva and Rodrigo Costa and Tina Keller-Costa},
  journal={Marine Drugs},
  year={2018},
  volume={16}
}
Octocorals (Cnidaria, Anthozoa Octocorallia) are magnificent repositories of natural products with fascinating and unusual chemical structures and bioactivities of interest to medicine and biotechnology. However, mechanistic understanding of the contribution of microbial symbionts to the chemical diversity of octocorals is yet to be achieved. This review inventories the natural products so-far described for octocoral-derived bacteria and fungi, uncovering a true chemical arsenal of terpenes… 

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References

SHOWING 1-10 OF 137 REFERENCES
Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743.
TLDR
This work focuses on the ET-743 (Yondelis) biosynthetic pathway, which is an approved anticancer agent obtained in low abundance from the tunicate Ecteinascidia turbinata and generated in suitable quantities for clinical use by a lengthy semisynthetic process.
Secondary Metabolites from Gorgonian Corals of the Genus Eunicella: Structural Characterizations, Biological Activities, and Synthetic Approaches
TLDR
The most promising biological activities of certain metabolites point to potential candidates for further development in pharmaceutical, cosmetic, and other industries, and are highlighted.
Antifungal potential of secondary metabolites involved in the interaction between citrus pathogens
TLDR
The fungal metabolites reported here were never described as antimicrobials until this date, demonstrating that co-cultures involving phytopathogens that compete for the same host is a positive strategy to discover new antifungal agents.
Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei.
  • J. Piel, D. Hui, S. Matsunaga
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
TLDR
Close related genes isolated from the highly complex metagenome of the marine sponge Theonella swinhoei, which is the source of the onnamides and theopederins, a group of polyketides that structurally resemble pederin are reported.
Antifungal and antiviral products of marine organisms
TLDR
The prospects of employing these compounds in clinical practice are promising in view of the wealth of these compounds from marine organisms, and the possibility to use those known to have distinctly different mechanisms, good bioavailability, and minimal toxicity in combination therapy remains to be investigated.
Host-microbe interactions in octocoral holobionts - recent advances and perspectives
Octocorals are one of the most ubiquitous benthic organisms in marine ecosystems from the shallow tropics to the Antarctic deep sea, providing habitat for numerous organisms as well as ecosystem
Bioactive Phenylalanine Derivatives and Cytochalasins from the Soft Coral-Derived Fungus, Aspergillus elegans
TLDR
Cytochalasins 5, 6, 8 and 9 showed strong antifouling activity against the larval settlement of the barnacle Balanus amphitrite, with the EC50 values ranging from 6.2 to 37 μM, the first report of antifOUling activity for this class of metabolites.
Functional Gene-Guided Discovery of Type II Polyketides from Culturable Actinomycetes Associated with Soft Coral Scleronephthya sp
TLDR
6 Micromonospora strains and 4 Streptomyces strains were found to be with the potential for producing aromatic polyketides based on the analysis of KSα (ketoacyl-synthase) gene in the PKS II (type II polyketide synthase) Gene cluster, suggesting their potential in synthesizing angucyclines e.g. jadomycin.
Induced Marine Fungus Chondrostereum sp. as a Means of Producing New Sesquiterpenoids Chondrosterins I and J by Using Glycerol as the Carbon Source
Chondrostereum sp., a marine fungus isolated from a soft coral Sarcophyton tortuosum, can yield hirsutane framework sesquiterpenoids. However, the metabolites profiles vary dramatically with the
Ecological Role of A Softcoral-Associated Bacterium Arthrobacter sp. on Marine Biofilm-Forming Bacteria
A marine bacterium species associated with softcoral Sinularia sp. collected from vicinity of Peucang island, Ujung Kulon, West Java, was successfully screened for estimating its ecological role
...
1
2
3
4
5
...