Bioactive Prenylhydroquinone Sulfates and a Novel C31 Furanoterpene Alcohol Sulfate from the Marine Sponge, Ircinia Sp.

  title={Bioactive Prenylhydroquinone Sulfates and a Novel C31 Furanoterpene Alcohol Sulfate from the Marine Sponge, Ircinia Sp.},
  author={Giuseppe Bifulco and Ines Bruno and Luigi Minale and Raffaele Riccio and C{\'e}cile Debitus and G Bourdy and Aude Vassas and Jacques Lavayre},
  journal={Journal of Natural Products},
Isolation of Hydroxyoctaprenyl-1′,4′-hydroquinone, a new Octaprenylhydroquinone from the Marine Sponge Sarcotragus spinosulus and Evaluation of its Pharmacological Activity on Acetylcholine and Glutamate Release in the Rat Central Nervous System
These findings indicate that the compounds isolated from S. spinosulus can significantly modulate the release of glutamate and acetylcholine in the rat hippocampus and cortex and might, therefore, represent the prototype of a new class of drugs regulating glutamatergic and cholinergic transmission in the mammalian central nervous system. Expand
Kinase Inhibitors from Marine Sponges
Marine sponges have yielded over 70 novel compounds to date that exhibit significant inhibitory activity towards a range of protein kinases, which belong to diverse structural classes and are ordered based upon the kinase that they inhibit. Expand
Cytotoxic Effect of Geranylphenol Derivatives in the Human Breast Cancer Cell Line MDA-MB-231 and Gastric Cancer Cell Line MKN74
Considering that compounds 2 and 7 were the most potent compounds inducing cell death, and were able to decrease the expression of retinoblastoma protein and cyclin D1, proteins usually altered in different types of cancers, they appear as promising therapeutic agents against cancer. Expand
Free Radical Scavenging and Anticollagenase Properties of Sargachromanol I from Myagropsis myagroides
The present study investigated the free radical scavenging activity and antiwrinkle properties of methanol extract, hexane, chloroform, ethyl acetate, and butanol partition fractions of MyagropsisExpand
Sponges: A Reservoir of Genes Implicated in Human Cancer
This review compiles current knowledge of cancer-related genes/proteins in marine sponges to provide an insight into the metazoan ancestor genome/ Proteome features. Expand
Antifungal toxicity of linear geranylphenol. Influence of oxigenate substituents.
The toxicity of the analyzed compounds is selective towards fungi, which makes them a very attractive family for the development of future drugs. Expand
Marine Sponges and Bacteria as Challenging Sources of Enzyme Inhibitors for Pharmacological Applications
This review reports on secondary metabolites with enzyme inhibitory activity from marine sponges and bacteria as promising sources of enzyme inhibitors for pharmacological applications, focusing on kinase inhibitors. Expand
Antiproliferative effect and apoptotic activity of linear geranylphenol derivatives from phloroglucinol and orcinol.
It was found that compounds 12 and 13, induced changes in mitochondrial membrane permeability in those cancer cell lines, and such induction was associated with the depletion of mitochondrial membrane potential. Expand
Marine Natural Products from New Caledonia—A Review
This review highlights the tremendous marine diversity in New Caledonia, and offers an outline of the vast possibilities for natural products, especially in the interest of pursuing collaborative fundamental research programs and developing local biotechnology programs. Expand


Receptor-ligand interactions : a practical approach
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Interpretation of the ultraviolet spectra of natural products
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